中国组织工程研究2017，Vol.21Issue(36)：5873-5878,6.DOI:10.3969/j.issn.2095-4344.2017.36.023
细胞因子与膝骨关节炎关节软骨损伤的修复
Regulatory factors in the articular cartilage repair of knee osteoarthritis
摘要
Abstract
BACKGROUND:Knee osteoarthritis is a joint and articular cartilage degenerative disease,and its biological changes mainly include proliferation and apoptosis of chondrocytes.Articular cartilage holds poor regeneration ability,and tissue-engineered cartilage is of great significance for the articular cartilage repair,while cytokines is a major concem for this repair process.OBJECTIVE:To overview the main regulatory factors involved in the articular cartilage repair and chondrocyte apoptosis.METHODS:PubMed and WanFang databases were retrieved for the literature addressing articular cartilage repair and main regulatory factors involved in articular cartilage repair and chondrocyte apoptosis published from 1999 to 2016.Finally 44 eligible articles were included for analysis.RESULTS AND CONCLUSION:Various cytokines in different human tissues are closely related to articular cartilage repair,chondrocyte apoptosis and pathological changes of osteoarthritis,which are involved in chondrocyte damage,degradation of cartilage matrix,synovial degeneration and periostosis.There is an increase in the levels of interleukin 1 β and 6,and tumor necrosis factor α following articular cartilage injury.Thereafter,blocking the expression of these cytokines can protect the articular cartilage from damage.Insulin-like growth factor and transforming growth factor play an important regulatory effect on the chondrocyte proliferation and matrix synthesis.Furthermore,various cytokines regulate the articular cartilage repair and reconstruction via complicated pathways.关键词
组织构建/软骨组织工程/关节软骨损伤/修复/细胞因子分类
医药卫生引用本文复制引用
朱瑜琪,王智耀,张帅,宁德花..细胞因子与膝骨关节炎关节软骨损伤的修复[J].中国组织工程研究,2017,21(36):5873-5878,6.基金项目
中国中医科学院眼科医院院级科研启动基金项目(201408) （201408）
the Research Initiation Foundation of Eye Hospital,China Academy of Chinese Medical Sciences,No.201408 （）
