中国康复理论与实践2018，Vol.24Issue(4)：427-431,5.DOI:10.3969/j.issn.1006-9771.2017.00.003
近红外脑功能成像对卒中后抑郁神经机制的研究
Neural Mechanism of Post-stroke Depression:A Functional Near-infrared Spectroscopy Study
摘要
Abstract
Objective To observe the change of the relative concentration of oxygenated hemoglobin in the frontal cortex during cognitive processing in patients with post-stroke depression (PSD), and to discuss the neural mechanism and changes of working memory function of PSD preliminarily. Methods From February to August,2017,20 patients with PSD(PSD group)and 20 patients with non-depressive(con-trol group)were recruited.NIRSport portable functional near-infrared spectroscopy system was used to observe the change of the relative concentration of hemoglobin in the frontal cortex during the emotional face gender judgment task and"1-back"working memory task. Results Compared with the control group,the change of the relative concentration of oxygenated hemoglobin in the pre-frontal cortex was significantly lower after the negative emotion faces were presented in PSD group(t=3.872,P<0.001).In the implementation of the"1-back",the change of the relative concentration of oxygenated hemoglo-bin in the left prefrontal cortex was significantly lower in PSD group than in the control group(t=2.475,P<0.05), however,there was no significant difference in the change in the right prefrontal cortex between two groups(t=1.773,P=0.084). Conclusion The prefrontal cortex activity decrease in patients with PSD after the negative emotion faces were present-ed.The left prefrontal working memory function is impaired.The patients with PSD have disorder of oxygen me-tabolism in the prefrontal lobe.关键词
卒中后抑郁/近红外脑功能成像/前额叶/神经机制/工作记忆Key words
post-stroke depression/functional near-infrared spectroscopy/frontal cortex/neural mechanism/working memory分类
医药卫生引用本文复制引用
李泓钰,王强,杜晓霞,王静,徐舒,王曼,宋鲁平..近红外脑功能成像对卒中后抑郁神经机制的研究[J].中国康复理论与实践,2018,24(4):427-431,5.基金项目
1.中央级公益性科研院所基本科研业务费专项资金项目(No.2016CZ-6) （No.2016CZ-6）
2.中国康复研究中心项目(No.2017ZX-12)Supported by Special Fund Project for Basic Scientific Research Business of Central Public Scientific Research Insti-tute(No.2016CZ-6)and China Rehabilitation Research Center Project(No.2017ZX-12) （No.2017ZX-12）
