中国临床药理学杂志2018，Vol.34Issue(1)：25-29,5.DOI:10.13699/j.cnki.1001-6821.2018.01.007
头孢硫脒最低抑菌浓度及其影响因素研究
Study on minimum inhibitory concentrations and its influence factors of cefathiamidine
薛峰 1李耘 1吕媛 1刘健 1杨维维 1张佳1
作者信息
- 1. 北京大学第一医院临床药理研究所,北京100034
- 折叠
摘要
Abstract
Objective To evaluate the minimum inhibitory concentration (MIC) and influence factors of cefathiamidine against clinical isolates from recent years in China.Methods MIC were tested by two fold agar dilution method.The effect of various experimental conditions (such as inoculation quantity,pH value of medium,percentage of serum)on MIC of cefathiamidine was evaluated.Results A total of 794 clinical strains were tested and cefathiamidine had showed excellent antibacterial activity against gram-positive bacterial.The MIC90 of cefathiamidine against methicillin-susceptible S.aureus (MSSA) and S.epidermidis (MSSE)were 0.50,0.12 mg · L-1,respectively.The MIC90 values of cefathiami-dine had against penicillin-susceptible S.pneumoniae (PSSP) and peni-cillin-nonsusceptible S.pneumoniae(PNSSP) were 0.12 mg· L-1 and not more than 1 mg · L-1,respectively.Against S.pyogenes,the MIC90 was 8 μg · L-1.The MIC90 of cefathiamidine against ampicillin-susceptible E.faecalis and E.faecium were 1,16 mg · L-1,respectively.The MIC90 of cefathiamidine against ampicillin-susceptible Haemophilus spp.and Moraxella catarrhalis were not more than 4 mg L-1 Cefathiamidine also had some antibacterial activity against gram-positive anaerobia.The factors including inoculation quantity,pH value of medium and percentage of serum had no effect on MIC values.Conclusion Cefathiamidine exhibited good activity against gram-positive bacterial including Enterococcus spp..关键词
头孢硫脒/体外抗菌作用/最低抑菌浓度/肠球菌Key words
cefathiamidine/in vitro antibacterial activity/minimum inhibitory concentration/Enterococcus spp.分类
医药卫生引用本文复制引用
薛峰,李耘,吕媛,刘健,杨维维,张佳..头孢硫脒最低抑菌浓度及其影响因素研究[J].中国临床药理学杂志,2018,34(1):25-29,5.
