中国临床药理学杂志2018，Vol.34Issue(1)：85-88,91,5.DOI:10.13699/j.cnki.1001-6821.2018.01.023
微小RNA对核受体调控药物代谢酶和转运体的研究现状
Research status of microRNA-dependent control of drug metabolic enzymes and transporters mediated by nuclear receptors
摘要
Abstract
Nuclear receptors (NRs) is a class of ligand-dependent transcription factor superfamily that regulate the transcription of target genes through endogenous or exogenous ligand activation.Nuclear receptors play an important role in the transcriptional regulation of drug metabolic enzymes and transporters.MicroRNA is a class of endogenous non -coding RNAs with regulatory functions.The control of microRNAs on the expression of nuclear receptors can affect the expression of drug metabolic enzymes and transporters,thus affecting the drug efficacy,adverse drug reactions and drug interactions.This paper systematically reviews the effects of microRNA on the regulation of drug metabolic enzymes and transporters mediated by several important nuclear receptors.关键词
微小RNA/核受体/代谢酶和转运体/调控Key words
microRNA/nuclear receptor/metabolic enzyme and transporter/regulation分类
医药卫生引用本文复制引用
叶容芳,熊玉卿..微小RNA对核受体调控药物代谢酶和转运体的研究现状[J].中国临床药理学杂志,2018,34(1):85-88,91,5.基金项目
国家自然科学基金资助项目(81673506) （81673506）
