中国临床药理学杂志2018，Vol.34Issue(2)：99-101,3.DOI:10.13699/j.cnki.1001-6821.2018.02.001
多潘立酮胶囊联合替普瑞酮对慢性萎缩性胃炎伴肠上皮化生患者的临床研究
Clinical trial of doperridone capsule combined with tipurone in the treatment of patients with chronic atrophic gastritis and intestinal metaplasia
摘要
Abstract
Objective To evaluate the clinical effect of doperridone capsule combined with tipurone in the treatment of chronic atrophic gastritis with intestinal metaplasia.Methods Eight-six patients with chronic atrophic gastritis and intestinal metaplasia were divided into control group and treatment group,each group 43 cases.Control group was treated with doperridone capsule 10 mg,tid,oral.Treatment group was treated with tipurone 50 mg on the basis of control group,tid,oral.All the patients were treated for 8 weeks.The clinical effect,symptom score,tumor necrosis factor-α(TNF-α),interleukin-8 (IL-8),pepsinogen Ⅰ/pepsinogen Ⅱ (PGR),and adverse drug reactions in two groups were observed.Results After treatment,total effective rates of treatment group and control group were 90.70％ (39 cases/43 cases),72.09％ (31 cases/43 cases),with significant difference (P ＜ 0.05).Symptom score of treatment group and control group were 8.48 ± 1.15,12.64±1.65,TNF-α were (1.13 ±0.15),(1.88 ±0.26)mg · L-1,IL-8 were (7.62 ±0.94),(8.86 ± 1.80)ng · L-1,PGR were 27.16 ±4.07,22.40 ± 2.68,all with significant difference (all P ＜ 0.05).The adverse drug reactions in two groups were abdominal pain,nausea,dry mouth and dizziness,the incidence of adverse drug reactions in control group and treatment group were 18.60％ (8 cases/43 cases) and 9.30％ (4 cases/43 cases),with no statistical difference (P ＞ 0.05).Conclusion Clinical effect of doperridone capsule combined with tipurone in the treatment of chronic atrophic gastritis with intestinal metaplasia is better than tipurone alone,can effectively adjust the levels of TNF-α and IL-8,improve PGR.关键词
慢性萎缩性胃炎/肠上皮化生/多潘立酮胶囊/替普瑞酮/肿瘤坏死因子-α/白细胞介素-8/胃蛋白酶原Ⅰ/胃蛋白酶原ⅡKey words
chronic atrophic gastritis/intestinal metaplasia/polyperridone capsule/tipurone/tumor necrosis factor-α/interleukin-8/pepsinogen Ⅰ/pepsinogen Ⅱ分类
医药卫生引用本文复制引用
郭明浩,戴明,郭遂成..多潘立酮胶囊联合替普瑞酮对慢性萎缩性胃炎伴肠上皮化生患者的临床研究[J].中国临床药理学杂志,2018,34(2):99-101,3.基金项目
新疆维吾尔自治区自然科学基金资助项目(2016D01C178) （2016D01C178）
