中国临床药理学杂志2018，Vol.34Issue(2)：117-119,3.DOI:10.13699/j.cnki.1001-6821.2018.02.007
利培酮在精神分裂症患者中的血清药物浓度/剂量比影响因素研究
Influential factors of serum concentration/dosage ratio for schizophrenia patients after oral administration of risperidone
摘要
Abstract
Objective To investigate the influential factors of serum drug concentration/dosage ratio (C/D) for schizophrenia patients after oral administration of risperidone.Methods Medical records of inpatients who received oral administration of risperidone in Guangzhou Huiai Hospital during 2016 were consulted and the C/Ds were calculated.Effects of age,gender,dosage form,combined medication,comorbidity and serum concentration ratio of 9-OH risperidone and risperidone were evaluated.Results C/D in patients aged 60 or older was (10.06 ± 6.61) ng · mL-1 · mg-1 · d.It was significantly larger than those under 60 years old,which were (7.82 ± 3.31) and (8.02 ±4.05) ng · mL-1 · mg-1 · d for 40-59 and under 40 years old,respectively.In addition,C/D was decreased with the increase of 9-OH risperidone/ risperidone ratio.The C/D were(10.96 ±6.46),(8.71 ±4.45)and (6.30 ± 2.99) ng · mL-1 · mg-1 · d for 9-OH risperidone/risperidone ratio ＜ 1,1-10 and ＞ 10,respectively.Gender,dosage form andthe major combined medications and comorbidities in the recruited patients hardly affected the C/D of oral risperidone.Conclusion The dose of risperidone that administered to the aged should be reduced properly.Serum concentration ratio of 9-OH risperidone and risperidonehas a potential to be used as an indirect index of the activity of metabolic enzymes.关键词
利培酮/浓度/剂量比/影响因素Key words
risperidone/concentration/dosage ratio/influential factor分类
医药卫生引用本文复制引用
卢浩扬,江晓佳,尚德为,倪晓佳,王占璋,张明,李健,温预关..利培酮在精神分裂症患者中的血清药物浓度/剂量比影响因素研究[J].中国临床药理学杂志,2018,34(2):117-119,3.基金项目
广州市科技计划基金资助项目(201509010012) （201509010012）
广州市医学重点学科基金资助项目(2017年至2019年) （2017年至2019年）
