中国临床药理学杂志2018，Vol.34Issue(2)：161-164,4.DOI:10.13699/j.cnki.1001-6821.2018.02.019
头孢硫脒在Beagle犬的药代动力学
Pharmacokinetics of cefathiamidine in Beagle dogs
张朴 1魏敏吉 1孔申申2
作者信息
- 1. 北京大学第一医院临床药理研究所,北京100034
- 2. 北京大学第一医院动物实验室,北京100034
- 折叠
摘要
Abstract
Objective To study the pharmacokinetics of cefathiamidine in Beagle dogs.Methods Six Beagle dogs received cefathiamidine at a single injection of 60 mg · kg-1.The concentrations of cefathiamidine in plasma were determined by a validated HPLC-MS/MS.The pharmacokinetics parameters were calculated by using WinNonlin program.Results After a single injection of 60 mg · kg-1 cefathiamidine,the pharmacokinetics parameters for cefathiamidine were as follows:t1/2 was (0.42 ± 0.04) h,tmax was (6.00 ± 4.00) × 10-2 h,Cmax was (302.47 ±35.39) μg mL-1,AUC0-t was (137.48 ± 31.79)μg · mL-1 · h,AUC0-inf was (137.69 ± 31.20) μg · mL-1 h.Conclusion Cefathiamidine shows fast elimination characteristics.关键词
头孢硫脒/药代动力学/液相-串联质谱法Key words
cefathiamidine/pharmacokinetics/HPLC-MS/MS分类
医药卫生引用本文复制引用
张朴,魏敏吉,孔申申..头孢硫脒在Beagle犬的药代动力学[J].中国临床药理学杂志,2018,34(2):161-164,4.
