中国临床药理学杂志2018，Vol.34Issue(2)：169-172,4.DOI:10.13699/j.cnki.1001-6821.2018.02.021
基于变异系数权重的模糊物元模型评价大黄不同提取部位降血脂的效果
Evaluating the effect of reducing blood lipid in different parts of Rheum palmatum L. with Fuzzy matter-element model based on variation coefficient weight
摘要
Abstract
Objective To investigate the effect of reducing blood lipid in three effective parts of Rheum palmatum L.based on variation coefficient weight.Methods First of all,the SD rat model of hyperlipidemia was given the water extract,the ethanol extract and the ethyl acetate extract of Rheum palmatum L.,then the content of total cholesterol (TC),high densitylipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),triglyceride (TG) in serum were determined and general survival of rats was analyzed.Then using fuzzy matter-element model on variation coefficient weight to evaluate the comprehensive reducing blood lipid effect of different extract parts of Rheum palmatum L..In the end,combining with the result of the value of Euclid approach degree,compared the effect of normal group (M1),the model group (M2),the positive control group (Xuezhikang,M3),the water extract group(M4),the ethanol extract group (M5),the ethyl acetate extract group (M6) of blood lipid.Results Compared with model group,the water extract part and the ethanol extract part of Rheum palmatum L.could reduce the congtents of TC,LDL-C,TG and rise HDL-C.Combining with the result of the value of Euclid approach degree,the water extract was 0.74,the ethanol extract was 0.54.Combining with the result of the value of Euclid approach degree,the order of its magniude is M3 ＞ M4 ＞ M1 ＞ M5 ＞ M6 ＞ M2.Conclusion The water extract part is the effective part of reducing blood lipid.The method and model can be used to objectively evaluate the comprehensive effect of reducing blood lipid of Rheum palmatum L.'s three extracted parts.关键词
大黄/降血脂/模糊物元模型/变异系数权重Key words
Rheum palmatum L./reduce blood lipid/fuzzy matter-element model/variation coefficient weight分类
医药卫生引用本文复制引用
杨蕊菁,顾家珲,朱顺娟,李少泓,夏鹏飞,赵磊..基于变异系数权重的模糊物元模型评价大黄不同提取部位降血脂的效果[J].中国临床药理学杂志,2018,34(2):169-172,4.基金项目
国家自然科学基金资助项目(81660577) （81660577）
甘肃省中医药管理局科研基金资助项目(GZK-2014-77) （GZK-2014-77）
陇药产业发展专项基金资助项目(甘财经(2015) 164号) （甘财经(2015）
高等学校科学研究自筹经费基金资助项目[甘教技(2015)13号] （2015）
