中国临床药理学杂志2018，Vol.34Issue(2)：173-176,180,5.DOI:10.13699/j.cnki.1001-6821.2018.02.022
结膜下注射氨基糖苷类抗菌药物的有效性和安全性评价
Review of the efficacy and safety of subconjunctival injection of aminoglycoside antimicrobials
摘要
Abstract
Objective To systematically evaluate the efficacy and safety of aminoglycoside antibiotics in the treatment of ocular infection through subconjunctival injection.Methods PubMed,EmBase,Cochrane library,Wanfang and CNKI databases were searched from inception until March 2017 to investigate clinical trials about subconjunctival injection of aminoglycoside antimicrobials for the treatment of eye infection.Systematic evaluation was used to analyze the main indexes such as the cure rate of eye infection,the drug concentration in aqueous humor,the occurrence of eye pain after injection and the incidence of conjunctival edema.Results A total of 18 randomized controlled trials were enrolled in our study.The results showed that the cure rate of eye infection through subconjunctival injection of aminoglycoside antibiotics was excellent and an adequate aqueous humor concentration could be attained.No systemic toxicity was found,but the incidences of eye pain (39.62％) and conjunctival edema (72.58％) were high.Conclusion Subconjunctival injection of aminoglycoside antibiotics was effective.Considering the low quality of included studies,the safety of subconjunctival injection of aminoglycoside antibiotics needs to be further verified.关键词
结膜下注射/氨基糖苷类/有效性/安全性/系统评价Key words
subconjunctival injection/aminoglycoside/efficacy/safety/systematic review分类
医药卫生引用本文复制引用
李安娜,邱婷婷,张弨..结膜下注射氨基糖苷类抗菌药物的有效性和安全性评价[J].中国临床药理学杂志,2018,34(2):173-176,180,5.基金项目
北京大学第三医院重点基金资助项目(77476-05) （77476-05）
