中国药房2018，Vol.29Issue(8)：1061-1065,5.DOI:10.6039/j.issn.1001-0408.2018.08.12
浙江省11家医院2010-2015年双膦酸盐类药物治疗乳腺癌骨转移相关骨损害及疼痛的利用研究
Study on Utilization of Bisphosphonates Drugs in the Treatment of Bone Metastasis Associated Bone Damage and Pain of Breast Cancer in 11 Hospitals of Zhejiang Province during 2010-2015
摘要
Abstract
OBJECTIVE:To investigate the utilization and trend of bisphosphonates drugs in patients with bone metastasis of breast cancer from Zhejiang province,so as to provide reference for the further promotion of their rational use. METHODS:The utilization of this type of drugs in 11 hospitals of Zhejiang province during 2010-2015 was analyzed statistically,counted and ranked by using the method of cost ranking analysis and DDDs analysis in the respect of amount,DDDs,DDC,etc. RESULTS:The amount of bisphosphonates drugs was increased steadily in 6 years(increasing greatly in 2011),increased by 96.26% in 2015,compared to 2010. Top 3 drugs in the list of amount were Zoledronic acid for injection(imported),Zoledronic acid for injection(domestic)and Pamidronate disodium for injection. Among them,Zoledronic acid for injection(imported)basically showed an upward trend,while Pamidronate disodium for injection showed decline trend. Top 3 drugs in the list of DDDs were Zoledronic acid for injection(domestic),Zoledronic acid for injection(imported)and Pamidronate disodium for injection;DDDs of Zoledronic acid for injection(domestic)and Zoledronic acid for injection(imported)were generally on the rise,while that of Pamidronate disodium for injection showed an overall downward trend. B/A value of bisphosphonates ranged 0.33-2.00,among which B/A value of Zoledronic acid for injection(domestic)was 2.00 and that of Zoledronic acid for injection(imported)was 0.50 during 2012-2015. The first and second drugs in the list of DDC were Clodronate disodium for injection and Zoledronic acid for injection(imported). CONCLUSIONS:The total amount of bisphosphonates drugs in patients with bone metastasis of breast cancer from 11 hospitals of Zhejiang province during 2010-2015 was increased steadily. Some varieties of second and third generation bisphosphonates with definite curative effect,good safety and reasonable price are dominant in clinical use. The selection and use of bisphosphonates is basically reasonable,but price is still the primary factor restricting the further wide application of some varieties.关键词
双膦酸盐类药物/乳腺癌骨转移/骨损害/疼痛/药物利用研究/使用金额/用药频度/日均费用Key words
Bisphosphonates drugs/Bone metastasis of breast cancer/Bone damage/Pain/Drug utilization research/Amount/DDDs/DDC分类
医药卫生引用本文复制引用
曹莹莹,王增,方罗,戚雅君,余佳文,骆虹,宋俞..浙江省11家医院2010-2015年双膦酸盐类药物治疗乳腺癌骨转移相关骨损害及疼痛的利用研究[J].中国药房,2018,29(8):1061-1065,5.基金项目
国家自然科学基金资助项目(No.81773819) （No.81773819）
浙江省中医药科技计划项目(No.浙卫发〔2015〕74号-2016ZA038) （No.浙卫发〔2015〕74号-2016ZA038）
