中国药房2018，Vol.29Issue(8)：1091-1094,4.DOI:10.6039/j.issn.1001-0408.2018.08.19
我院祛瘀及清热类中药致新的和严重的不良反应298例分析
Analysis of 298 Cases of New and Severe ADR Induced by TCM for Removing Blood Stasis and Clearing Heat in Our Hospital
摘要
Abstract
OBJECTIVE:To investigate the characteristics and rules of new and severe ADR induced by TCM for removing blood stasis and clearing heat in our hospital,and to provide reference for safe drug use in clinic. METHODS:New and severe ADR induced by TCM for removing blood stasis and clearing heat reported to national ADR monitoring center were collected from our hospital during Jan. 2006-Dec. 2016. Those ADR cases were analyzed retrospectively in respects of gender,age,allergic history,route of administration,drug type and dosage form,occurrence time,organs/systems involved and clinical manifestations, outcome. RESULTS:Among 298 reports,the incidence of ADR in female(70.13%)was higher male(29.87%),especially in patients aged 50-59(21.48%);there were 77 allergic cases(25.84%). Route of administration was mainly oral administration (57.37%),and dosage form was mainly injection(25.50%). Main ADR-inducing drug was Chinese patent medicine(53.53%). ADR mostly occurred over 1 d after medication(48.32%). Systems/organs involved in ADR were mainly lesion of skin and its appendants,systemic damage and gastrointestinal damage. Main clinical manifestations were rash,contact dermatitis,pruritus, infusion reaction,chills,fever,nausea,vomiting,diarrhea,etc.After drug withdrawal or symptomatic treatment,97.99% patients were revered and cured. There was no death case. CONCLUSIONS:TCM for removing blood stasis and clearing heat causes most new and severe ADR.Clinical drug use should be monitored closely to reduce the occurrence of ADR.关键词
不良反应/祛瘀/清热/中药/新的/严重的/回顾性分析Key words
ADR/Removing blood stasis/Clearing heat/TCM/New/Severe/Retrospective analysis分类
医药卫生引用本文复制引用
刘洋,范峥,常馨予,韩丽娟,郭桂明..我院祛瘀及清热类中药致新的和严重的不良反应298例分析[J].中国药房,2018,29(8):1091-1094,4.基金项目
国家中医药管理局"十二五"重点专科建设项目(No.国中医药医政发〔2012〕2号-57) （No.国中医药医政发〔2012〕2号-57）
北京中医医院院级课题暨两院合作课题(No.YJ-201724) （No.YJ-201724）
