中国药理学与毒理学杂志2017，Vol.31Issue(9)：907-913,7.DOI:10.3867/j.issn.1000-3002.2017.09.007
溃疡性结肠炎内源性代谢物和肠道菌群变化研究进展
Research progress on variations of endogenous metabolites and intestinal bacteria in ulcerative colitis
摘要
Abstract
Ulcerative colitis(UC)is a common chronic intestinal inflammation and one of the modern diseases that are difficult to cure effectively.Increasing attention is paid on UC based on metabonomic and microbe analysis. In this article, we review the recent advances in endogenous metabolites including amino acid, energy metabolism and lipid metabolism, intestinal bacteria including Firmicutes, Bacte-roidetes, Proteobacteria and Actinobacteria as well as covariation between metabolites and intestinal bacteria in UC.Short chain fatty acid and tryptophan are used as examples to ecaborate on the important functions of metabolism of nutrients and intestinal bacteria in diseases and illustrate the contributions of intestinal bacteria to diseases.关键词
溃疡性结肠炎/代谢组学/肠道菌群Key words
ulcerative colitis/metabonomis/intestinal bacteria分类
医药卫生引用本文复制引用
李云,戴岳,夏玉凤..溃疡性结肠炎内源性代谢物和肠道菌群变化研究进展[J].中国药理学与毒理学杂志,2017,31(9):907-913,7.基金项目
国家自然科学基金(81374038)The project supported by National Natural Science Foundation of China(81374038) （81374038）
