中国药理学与毒理学杂志2017，Vol.31Issue(9)：934-938,5.DOI:10.3867/j.issn.1000-3002.2017.09.011
有机氯杀虫剂致脂肪酸和胆汁酸代谢异常的研究进展
Metabolic disorder of fatty acids and bile acids caused by organochlorine pesticides:research progress
摘要
Abstract
Organochlorine pesticides(OCP)exist widely in the environment,which may threaten human health and cumulate for years once absorbed in the body.OCP metabolites in the body are associated with metabolic disorders.In vivo and in vitro exposure of OCP could enhance hepatic fatty acid synthesis, and interfere in the β-oxidation of fatty acids by impairing the function and structure of mitochondria in hepatocytes. Moreover, OCP can increase secondary bile acid formation by modulating of gut microbiota and reduceing ileal bile acid re-absorption,resulting in compensatory increase of hepatic bile acid synthesis. This review summarizes the mechanism of fatty acid and bile acid metabolic abnormalities caused by OCP.关键词
有机氯杀虫剂/脂肪酸/胆汁酸/肠道菌群Key words
organochlorine pesticides/fatty acids/bile acids/gut microbiota分类
医药卫生引用本文复制引用
刘倩,邵文涛,顾爱华,蒋兆彦..有机氯杀虫剂致脂肪酸和胆汁酸代谢异常的研究进展[J].中国药理学与毒理学杂志,2017,31(9):934-938,5.基金项目
国家自然科学基金(81570574)The project supported by National Natural Science Foundation of China(81570574) （81570574）
