摘要
Abstract
Objective To assess the effect of Shenqi Fuzheng Injection combined with docetaxel on cellular immune function in patients with terminal breast cancer. Methods One hundred hospitalized patients with terminal breast cancer were collected and divided into study group (Shenqi Fuzheng Injection with docetaxel routine chemotherapy) and control group (normal saline with routine chemotherapy), 50 cases in each group. All patients were treated with routine chemotherapy, the patients in the study group were treated with Shenqi Fuzheng Injection with docetaxel on the basis of control. The curative effect was assessed, and the T lymphocyte subpopulation and dendritic cell markers were detected at the end of the treatment. Results The rate of complete and partial remission in study was 60 % (30 cases ), which was higher than that of control (34 %, 17 cases, P<0.05). The percents of CD 3+ (66.48 ± 9.76)%, CD 4+ (42.89 ± 8.66)%, and CD 4/CD 8 rate (1.88±0.84)% in post-treatment were higher than that of pre-treatment (59.68±8.54)%, (22.67±5.59)% and (1.06±0.56)% (P<0.05) and control (61.59±8.77)%, (25.16±4.69)% and (1.23±0.71)% (P<0.05), but the percent of CD8+ in study group (22.55±3.79)% was lower than that in pretreatment (29.36±4.62)% and control (28.87±5.19)% (P<0.05). In addition, the percents of CD80, CD83 and CD8 of study group in post-treatment (9.29±2.78)%, (12.48±3.26)% and (48.17±11.21)% were higher than those in pre-treatment (6.76±1.59)%, (8.26±2.15)% and (35.49±8.73)% (P<0.05), but there was no significant difference between pre-treatment and post-treatment in control group. Adverse event of study group was lower than that in control group (28% vs 52%, P<0.05). Conclusion Shenqi Fuzheng Injection combined with docetaxel can improve the immune function in patients with terminal breast cancer, and Shenqi Fuzheng Injection can be used as adjuvant drug for reducing toxicity and enhancing efficacy in the process of chemotherapy of breast cancer.关键词
乳腺癌/参芪扶正注射液/中医药/化疗Key words
Breast cancer/Shenqi Fuzheng Injection/traditional Chinese medicine/chemotherapy分类
医药卫生
