中成药2018，Vol.40Issue(3)：524-529,6.DOI:10.3969/j.issn.1001-1528.2018.03.004
黄芩-黄连药对防治D-半乳糖痴呆小鼠的作用机制
Preventive and therapeutic mechanism of the herbal pair, Scutellariae Radix and Coptidis Rhizoma on dementia-like mice induced by D-galactose
摘要
Abstract
AIM To investigate the preventive effects of herbal pair,Scutellariae Radix and Coptidis Rhizoma (SC),on Alzheimer's disease (AD),and its mechanism of action.METHODS Dementia mice induced by 8-week s.i.d subcutaneous injection of D-galactose (100 mg/kg),were simultaneously given respective,intragastric administration of SC crude drug at doses of 5,10,20 g/kg,or piracetam support at 0.75 g/kg,and isometrical distilled water was applied to the mice of normal control group.The mice had their learning and memory abilities checked by Morris water maze at intervals of four weeks and eight weeks since the start of the trial,and their blood and brain tissue biochemical indices measured at the end of the test.RESULTS Significantly shortened latent period in place navigation test and the time of enter into the original platform in the space exploration test were observed in the mice treated with 4-week D-galactose and SC (P ＜0.05 或 P ＜0.01).The 8-week intervention demonstrated SC capacity in the significant promotion of T-SOD activity,decreased blood MDA levels (P ＜ 0.01)and the brain AchE levels,and increased brain GSH-Px activity (P ＜ 0.01).CONCLUSION SC increases the concentration of acetylcholine in brain tissue and protects the central nervous tissue under oxidative stress,highlighting its therapeutic effect on AD.关键词
黄芩-黄连药对/D-半乳糖/痴呆/改善Key words
herbal pair of Scutellariae Radix and Coptidis Rhizoma/D-Galactose/dementia/improve分类
医药卫生引用本文复制引用
章常华,刘彤彤,邓可众,陈颖翀,林贵兵,叶荷平,涂秀英,盛军庆..黄芩-黄连药对防治D-半乳糖痴呆小鼠的作用机制[J].中成药,2018,40(3):524-529,6.基金项目
国家自然科学基金(81460622,81774194,81260660) （81460622,81774194,81260660）
江西省自然科学基金(20151BAB205077,20171BAB205095,20151BAB205079) （20151BAB205077,20171BAB205095,20151BAB205079）
江西省卫生和计划生育委员会科研计划项目(2016A024) （2016A024）
