中成药2018，Vol.40Issue(3)：530-536,7.DOI:10.3969/j.issn.1001-1528.2018.03.005
补血生乳颗粒对SD大鼠围产期毒性
Toxicity of Buxue Shengru Granules on perinatal rats
叶向锋 1谷陟欣 2彭帮杰 1宋潇 3叶惠煊 2赵李剑 2谢安4
作者信息
- 1. 中国医学科学院北京协和医学院新药安全评价研究中心,北京100050
- 2. 九芝堂股份有限公司(国家中医药工程学重点学科,国家企业技术中心),湖南长沙410021
- 3. 北京协和建昊医药技术开发有限责任公司北京100176
- 4. 湖南大学生物学院,湖南长沙410082
- 折叠
摘要
Abstract
AIM To investigate the toxicity of Buxue Shengru Granules (BSG,Astragali Radix,Angelicae sinensis Radix,Paeoniae Radix alba,etc.) to perinatal SD rats and their offspring to determine its safety.METHODS The respective BSG administration of 0,1,3,10 g/kg to the four groups rats,each with twenty-four female rats,started from the day 15 of gestation (GD15) through weaning when they were procured for the identification of the general condition,body weight and food ingestion.The offspring had their postnatal appearance observed the physiological development,reflexes development,behavior and fertility detected as well.RESULTS BSG gave neither significant influence on the rats' general condition,time of birth,body weight,and histological changes of organs during perinatal period;nor remarkable impact on the offspring's growth,development,nerves,endocrine,and reproductive system.CONCLUSION Data on BSG to rats maternal weight gain and food intake and to their offspring developmental landmarks,sexual maturation,or reflexes suggest that BSG gives no perinatal toxicity.关键词
补血生乳颗粒/围产期/毒性/大鼠Key words
Buxue Shengru Granules (BSG)/perinatal period/toxicity/rat分类
医药卫生引用本文复制引用
叶向锋,谷陟欣,彭帮杰,宋潇,叶惠煊,赵李剑,谢安..补血生乳颗粒对SD大鼠围产期毒性[J].中成药,2018,40(3):530-536,7.
