中成药2018，Vol.40Issue(3)：571-577,7.DOI:10.3969/j.issn.1001-1528.2018.03.012
桂枝茯苓透皮贴剂的制备
Preparation of Guizhi Fuling transdermal patch
摘要
Abstract
AIM To prepare Guizhi Fuling transdermal patch.METHODS With kinds of pressure-sensitive adhesive and penetration enhancer,kind and consumption of solvent,drug loading as influencing factors,appearance,formability and viscidity of patch,extract dispersion as evaluation indices,single factor test was applied to optimizing the preparation.And subsequent in vitro transdermal absorption test was performed to investigate the steady-state permeation rates of paeoniflorin,cinnamic acid and paeonol onto rat skins.RESULTS The optimal conditions were determined to be Duro-Tak 87-2677 polyacrylate pressure-sensitive adhesive (matrix),1 ∶ 0.5 for ratio of extract to propanediol (solvent),3％ azone as a penetration enhancer,and 20％ for drug loading,the obtained transdermal patch demonstrated both ideal initial adhesion force and holding adhesion force.These three constituents' average transdermal rates were 34.32,1.684,72.90 μg/(cm2 · h) with the average release rates of 26.81,1.523,111.8 μg/(cm2 · h),respectively,whose in vitro transdermal permeation curves conformed to Higuchi equation.CONCLUSION Guizhi Fuling transdermal patch processed with simple and stable preparation technique exhibits good in vitro transdermal permeation performance.关键词
桂枝茯苓透皮贴剂/制备/芍药苷/肉桂酸/丹皮酚/体外经皮渗透/单因素试验Key words
Guizhi Fuling transdermal patch/preparation/paeoniflorin/cinnamic acid/paeonol/in vitro transdermal permeation/single factor test分类
医药卫生引用本文复制引用
吴素香,闫冉,石森林,葛卫红..桂枝茯苓透皮贴剂的制备[J].中成药,2018,40(3):571-577,7.基金项目
国家自然科学基金项目(81274090) （81274090）
浙江省重点科技创新团队项目(2012R10044-01) （2012R10044-01）
