安徽中医药大学学报2018，Vol.37Issue(1)：72-76,5.DOI:10.3969/j.issn.2095-7246.2018.01.021
活血潜阳祛痰方对肥胖高血压大鼠血管紧张素Ⅱ及糖脂代谢的影响
Effect of Huoxue Qianyang Qutan Prescription on Angiotensin Ⅱ and Glycolipid Metabolism in Rats with Obesity and Hypertension
摘要
Abstract
Objective To explore the interventional effect of Huoxue Qianyang Qutan Prescription on angiotensin Ⅱ (Ang Ⅱ),homeostatic model assessment for insulin resistance (HOME-IR),and blood lipids in rats with obesity and hypertension.Methods Five-week-old male spontaneously hypertensive rats (SHRs) were fed with high-fat diet for 10 weeks to establish a rat model of obesity and hypertension,and then these rats were randomly divided into model group,traditional Chinese medicine (TCM) group,and Western medicine group.Wistar-Kyoto rat control group and SHR control group were also established.The rats in the TCM group were given Huoxue Qianyang Qutan Prescription by gavage,those in the Western medicine group were given valsartan by gavage,and those in the other three groups were given purified drinking water by gavage.Body mass index and systolic blood pressure (SBP) were measured after 8 weeks of treatment,as well as the level of Ang lⅡ in serum and the myocardium,fasting plasma glucose (FPG),and levels of insulin and blood lipids.Results In the rats with obesity and hypertension,Huoxue Qianyang Qutan Prescription significantly reduced the increased Lee index,SBP,FPG,total cholesterol,low-density lipoprotein cholesterol,HOME-IR,and Ang Ⅱ level in serum and the myocardium (all P＜0.05).Conclusion Rats with obesity and hypertension have severe endocrine-metabolic disorder,and Huoxue Qianyang Qutan Prescription can effectively reduce the level of Ang Ⅱ and improve abnormal blood lipid levels and insulin resistance.关键词
自发性高血压大鼠/肥胖/活血潜阳祛痰方/血管紧张素Ⅱ/胰岛素抵抗Key words
Spontaneous hypertensive rat/Obesity/Huoxue Qianyang Qutan Prescription/Angiotensin Ⅱ/Insulin resistance分类
医药卫生引用本文复制引用
芦波,周训杰,符德玉,桂明泰,姚磊,李建华,韩亚楠,龙敏,舒婷..活血潜阳祛痰方对肥胖高血压大鼠血管紧张素Ⅱ及糖脂代谢的影响[J].安徽中医药大学学报,2018,37(1):72-76,5.基金项目
上海市进一步加快中医药事业发展三年(2014-2016年)行动计划项目(ZY3-CCCX-3-3026) （2014-2016年）
高等学校博士学科点专项科研基金(20133107110011) （20133107110011）
上海市岳阳中西医结合医院高血压重点专病专科 （）
