北京生物医学工程2018，Vol.37Issue(2)：201-207,7.DOI:10.3969/j.issn.1002-3208.2018.02.016
基于微流控芯片SERS生物传感器的发展与应用
Development and application of SERS biosensor based on microfluidic chip
摘要
Abstract
Surface enhance Raman spectroscopy(SERS)as an emerging advanced trace analysis technique with ultra-sensitive and fingerprint-free features,achieves fast and non-invasive detection combined with microfluidic chip in optical fluid detection.SERS signals with the features of stability,reproduction,high-intensity and high-sensitivity are the prerequisites for obtaining valid bio-sensing information.A number of investigations demonstrate that noble metal nanoparticle aggregates of controllability or nanoparticle arrays are crucial for generating the above SERS signals.The research progress of certain aspects is summarized in this article,which includes the enhancement and reappearance of high-sensitivity SERS signals by using metal nanoparticle aggregates of controllability and solid SERS active substrate formed by utilizing electric and magnetic fields,the increasing effect of solid SERS substrate on body surface area,and the application of SERS biosensor in clinical immunoassay.This review provides references to further study on the mechanism of reproduction and enhancement of SERS signal by noble metal nanoparticles,especially the application of SERS bio-sensor,and offers scientific evidence for optimize design on solid SERS active substrates to achieve portable and intelligent SERS bio-sensor system.关键词
微流控芯片/表面增强拉曼光谱/免疫测定/SERS生物传感器/纳米粒子聚集体/固态SERS基底Key words
microfluidic chip/surface enhanced Raman spectroscopy/immunoassay/SERS biosensor/nanoparticle aggregate/solid SERS substrate分类
医药卫生引用本文复制引用
刘江涛,洪昕..基于微流控芯片SERS生物传感器的发展与应用[J].北京生物医学工程,2018,37(2):201-207,7.基金项目
国家自然科学基金(31271064)资助 （31271064）
