磁共振成像2018，Vol.9Issue(3)：161-165,5.DOI:10.12015/issn.1674-8034.2018.03.001
阿尔茨海默病脑磁共振氨基质子转移成像与临床心理量表评分的相关性研究
The correlation between brain MR amide proton imaging and scores of clinical psychometric scales in patients with Alzheimer's disease
摘要
Abstract
Objective:To evaluate the correlation between MR amide proton transfer (APT) imaging values of cerebral structures and neuropsychological scores in patients with Alzheimer's disease (AD).Materials and Methods:Twenty-one AD patients and 19 age-and sex-matched normal controls underwent APT and structural MR imaging.The magnetic resonance ratio asymmetry (MTRasym) values at 3.5 ppm of bilateral hippocampi (Hc),temporal white matter regions,occipital white matter regions and cerebral peduncles were measured on the oblique axial APT images.All the subjects were evaluated by Mini-Mental State Examination (MMSE) and clinical dementia rating (CDR).MTRasym (3.5 ppm) values of the cerebral structures between two groups were compared with independent-samples t test.Controlling for age and years of education,partial correlation analysis was used to investigate the correlation between the various MR imaging measures and MMSE,CDR scores among all the subjects.Results:Compared to normal controls,MTRasym (3.5 ppm) in bilateral hippocampi were significantly increased in AD patients [right:(0.86±0.32)％ and (1.42±0.35)％,t=5.158,P=0.000;left:(0.84±0.31)％ and (1.39±0.33)％.t=5.225,P=0.000].MTRasym (3.5 ppm) values of bilateral Hc were significantly negatively correlated with MMSE scores (right r=0.637,P=0.000.left r=-0.611,P=0.000) and positively correlated with CDR scores (right r=0.686,P=0.000.left r=0.658,P=0.000).Conclusions:APT imaging can show sensitively hippocampal abnormal metabolite based on increased proteins and peptides in patients with AD,which suggests the technique is a useful tool to diagnose AD and monitor the disease.关键词
阿尔茨海默病/海马/磁共振成像Key words
Alzheimer's disease/Hippocampus/Magnetic resonance imaging分类
医药卫生引用本文复制引用
王蕊,班允清,李春媚,娄宝辉,张晨,陈敏..阿尔茨海默病脑磁共振氨基质子转移成像与临床心理量表评分的相关性研究[J].磁共振成像,2018,9(3):161-165,5.基金项目
国家自然科学基金(编号:81771826、81361120392、81401404) （编号:81771826、81361120392、81401404）
北京自然科学基金(编号:7162171) （编号:7162171）
北京医院院级课题(编号:bj-2015-142)This research is funded by the National Natural Science Foundation of China (No.81771826,81361120392 and 81401404),Beijing Natural Science Foundation (No.7162171) and Beijing Hospital level (No.bj-2015-142). （编号:bj-2015-142）
