磁共振成像2018，Vol.9Issue(3)：186-191,6.DOI:10.12015/issn.1674-8034.2018.03.005
症状性颅内动脉粥样硬化斑块易损性的直方图纹理分析
Histogram texture analysis on vulnerability of symptomatic plaques in intracranial atherosclerosis
摘要
Abstract
Objective:The aim of the present study is to evaluate differences in histogram features between symptomatic and asymptomatic plaques in intracranial atherosclerotic disease on HR-MRI.Materials and Methods:This study population was retrospectively selected from patients with intracranial stenosis who underwent intracranial HR-MRI between January 2016 and January 2017,from whom all of the plaque features were extracted using CMR Tools and Image J software.Statistical analysis was performed using a logistic regression model.Results:A total of 133 plaques were identified in the 133 patients (mean age 58.5±11.4 years),of which 75 patients were considered with acute ischemic stroke and 58 patients were asymptomatic.T1 images would have a higher sensitivity to predict the vulnerability of atherosclerotic plaques by the quantitative histogram analysis compared with T2 and T1-enhancement images.Multiple logistic regression analysis showed that MLA (OR=1.301,95％ CI,1.036-1.633),IPH (OR=12.440,95％ CI,1.551-99.780) and CV (OR=3.476,95％ CI,1.513-7.985) were important predictors to define symptomatic plaques.Both the morphological and histogram features had been combined to classify the intracranial atherosclerotic plaques was better than the method on the single way,where the area under the curve (AUC) of ROC curve was 0.801.Conclusions:This study demonstrated that quantitative histogram analysis based on T1WI without enhancement could help distinguish acute symptomatic from asymptomatic plaques in intracranial atherosclerosis,and it is better than traditional method to differentiate acute symptomatic and asymptomatic intracranial atherosclerotic plaques.关键词
颅内动脉粥样硬化/磁共振成像/脑卒中Key words
Intracranial arteriosclerosis/MRI/stroke分类
医药卫生引用本文复制引用
史张,刘崎,陈海虎,李晶,田霞,张雪凤,彭雯佳,陈录广,陆建平,王莉..症状性颅内动脉粥样硬化斑块易损性的直方图纹理分析[J].磁共振成像,2018,9(3):186-191,6.基金项目
国家自然科学基金(编号:81670396、31470910) （编号:81670396、31470910）
上海市市级医院新兴前沿技术联合攻关项目(编号:SHDC12013110) （编号:SHDC12013110）
全军医学科研“十二五”计划重点课题(编号:BWS12J026)This work was supported in part by the National Natural Science Foundation of China (No.81670396,31470910).The Emerging Frontier Technology Joint Research Program of Shanghai Municipal Hospital of China (No.SHDC12013110).The "Twelfth Five-Year" Plan of the Medical Research of the Chinese People's Liberation Army (No.BWS12J026). （编号:BWS12J026）
