磁共振成像2018，Vol.9Issue(3)：197-201,5.DOI:10.12015/issn.1674-8034.2018.03.007
动态对比增强磁共振成像对急性胰腺炎血流灌注的研究
Dynamic contrast enhanced MRI for pancreatic perfusion in acute pancreatitis
摘要
Abstract
Objective:To study dynamic contrast enhanced MRI (DCE-MRI) for the normal pancreas and acute pancreatitis (AP).Materials and Methods:The institutional review board approved the study,written informed consent was obtained.Twenty patients without any pancreatic disorders (control group) and forty five patients with clinically proved AP were recruited in this study.All patients had performed MRI with T1WI,T2WI,fat suppression T2WI sequences,multiple flip angle T1WI-LAVA and T 1WI-LAVA dynamic contrast enhanced scan sequence.The OmitkDCEMRITool of Omni-Kinetics Version V2.0.10 (GE) was used to analyze the multiple flip angles T1WI-LAVA and T1WI-LAVA dynamic contrast enhanced imagings.The Ktrans,Vp and AUC values were measured in both AP group and Control group.The perfusion parameters of the head,body and tail of normal pancreas were compared by using the Wilcoxon singned-rank test,and the perfusion parameters of AP group and Control group were compared by Wilcoxon rank sum test.Results:The Ktrans,Vp and AUC values of AP were (0.417,0.132-0.746) ml/min,(0.058,0.028-0.12) and (4.467,3.594-7.447),respectively.The Ktrans,Vp and AUC values of normal pancreas were (0.762,0.389-0.918) ml/min,(0.222,0.111-0.347),(6.597,4.646-9.226),respectively.The Ktrans,Vp and AUC values of AP were lower than those of control group (all P＜0.05).The Vp value of normal pancreas was no statistically significant difference among the head,body and tail (all P＞0.05).The Ktrans and AUC values of normal pancreas were statistically significant difference between the head and body (all P＜0.05),as well as between the head and tail (all P＜ 0.05).But no statistical difference was found between the body and tail (all P＞0.05).Conclusions:DCE-MRI can quantify the microcirculation perfusion of the pancreas with noninvasive and no radiation,and lay the foundations of theory and practice for further study the AP perfusion.关键词
胰腺/胰腺炎/磁共振成像Key words
Pancreas/Pancreatitis/Magnetic resonance imaging分类
医药卫生引用本文复制引用
胡然,陈勇,解超莲,汤梦月,曾南林,陈天武,张小明,李昕..动态对比增强磁共振成像对急性胰腺炎血流灌注的研究[J].磁共振成像,2018,9(3):197-201,5.基金项目
四川省青年科技创新研究团队基金项目(编号:2011JTD0030)This research is funded by the project of the youth scientific and technological innovation research team of Sichuan Province (No.2011JTD0030). （编号:2011JTD0030）
