重庆医学2018，Vol.47Issue(10)：1305-1308,1313,5.DOI:10.3969/j.issn.1671-8348.2018.10.003
内皮素A受体拮抗剂预处理对犬体外循环后肾功能的影响
Influence of endothelin A receptor antagonist pretreatment on renal function after cardiopulmonary bypass in beagles
摘要
Abstract
Objective To observe the influence of endothelin A receptor antagonist pretreatment on renal function after cardiopulmonary bypass (CPB) in beagles.Methods A total of 18 male beagles were selected and allocated to 3 groups (n =6) by adopting the random number table method:sham operation group (Sham group),CPB group and endothelin A receptor antagonist (ETA) group.Sitaxsentan 0.7 mg/kg in the ETA group was infused by continuous pumping for 30 min at 1 h prior to CPB.The body temperature,mean arterial pressure (MAP) and arterial gas were collected.The concentrations of serum creatinine (Scr) and blood urea nitrogen (BUN) were detected.The renal tubular necrosis score was evaluated,and the expression levels of phosphorylated Akt (p-Akt),phosphorylated eNOS (p-eNOS) were also detected.Results Serum SCr and BUN levels at 2 h after CPB in the CPB and ETA group were significantly higher than those before operation (P＜0.05),and the ETA group was obviously lower than the CPB group (P＜0.05);the renal tubular necrosis score in the ETA group was obviously lower than that in the CPB group (P＜0.05).Expressions of p-Akt,p-eNOS in the ETA group were significantly higher than those in the CPB group(P＜0.05).Conclusion CPB might contribute to acute kidney injury,the endothelin A receptor antagonist pretreatment might alleviate acute kidney injury after CPB.关键词
体外循环/肾功能/内皮素A受体拮抗剂Key words
cardiopulmonary bypass/renal function/endothelia A receptor antagonists分类
医药卫生引用本文复制引用
白毅平,冯建国,刘力,龙翔,张亚兵,刘斌..内皮素A受体拮抗剂预处理对犬体外循环后肾功能的影响[J].重庆医学,2018,47(10):1305-1308,1313,5.基金项目
四川省科技厅科技支撑计划(2012FZ0121). （2012FZ0121）
