重庆医学2018，Vol.47Issue(10)：1322-1324,1328,4.DOI:10.3969/j.issn.1671-8348.2018.10.007
HAV疫苗干预对哮喘息儿治疗效果的影响
Impact of hepatitis A vaccine intervention on treatment effect in children with asthma
摘要
Abstract
Objective To investigate the impact of hepatitis A vaccine (HAV) intervention on clinical manifestations and impulse oscillometry (IOS) pulmonary function in children with asthma.Methods Eighty asthma children in the pediatric department of the Southwest Hospital of Third Military Medical University were selected as the control group,78 children were in the intervention group.The attenuated live HAV was adopted to conduct the intervention.The clinical manifestations and IOS pulmonary function were observed in 6 months and 12 mohths after inoculation.The case control study and analysis were performed.Results The symptom control and partial control rate at 6 months after HAV vaccine intervention in the intervention group was 89.8 ％,which was higher than 86.3 ％ in the control group,but the difference was not statistically significant (P＞0.05).The symptom control and partial control rate at 12 months after intervention in the intervention group was 92.3％,which in the control group was 87.6％,the asthma symptoms control situation in the intervention group was improved markedly,the difference was statistically significant (P＜0.05).The peripheral airway viscosity resistance (R5-R20) at 6 months after HAV vaccine intervention in the intervention group was lower than that in the control group,but there was no statistically significant difference (P＞ 0.05);Zrs,Fres,R5 at 12 months after intervention in the intervention group were lower than those in the control group,the difference was statistically significant (P＜0.05).Conclusion HAV vaccine intervention could improve clinical symptoms control and IOS lung function in children with asthma after one year.HAV vaccination has a protective effect on asthma in children.关键词
哮喘/疫苗/肝炎,甲型/干预性研究/儿童哮喘/IOS肺功能Key words
asthma/vaccines/hepatitis A/intervention studies/child asthma/IOS pulmonary function分类
医药卫生引用本文复制引用
余丹,陈建平,何念海..HAV疫苗干预对哮喘息儿治疗效果的影响[J].重庆医学,2018,47(10):1322-1324,1328,4.基金项目
国家自然科学基金面上项目(30600686). （30600686）
