重庆医学2018，Vol.47Issue(10)：1347-1350,4.DOI:10.3969/j.issn.1671-8348.2018.10.014
非酒精性脂肪性肝病患者血清维生素与抗氧化指标检测分析
Analysis on detection of serum vitamins and antioxidative indexes in patients with non-alcoholic fatty liver disease
摘要
Abstract
Objective To investigate the serum levels of vitamins and antioxidative indexes as well as theircorrelations with nonalcoholic fatty liver disease (NAFLD),and to analyze the influence of different detection methods on same index detection result.Methods Eighty NAFLD patients diagnosed by ultrasound were chosen for detecting the indexes,including the levels of serum RBP,vitamin A (VA),vitamin D (VD,ELISA and enzyme donor competition method),vitamin E (VE),vitamin B12 (VB12),and antioxidative indexes,including malondialdehyde (MDA),superoxide dismutase (SOD,pyrogallol substrate method and WST-1 method) and reduced glutathione (GSH).Results Compared with the normal reference values,the deficiency rate of serum RBP,VA,VD,VE and SOD in NAFLD patients were 11.6％,38.4％,7.9％,86.0％ and 27.9％ respectively.The serum GSH level in the NAFLD group was lower than that in the healthy control group (P＜0.01).Detecting serum VD and SOD by different detection method found that the difference among different detection methods had statistical significance (P＜0.01).Conclusion The levels of serum VA,VE,GSH and SOD in NAFLD patients are significantly reduced.These detection indicators have the important significance for clinical diagnosis of NAFLD.关键词
肝疾病/脂肪类/非酒精性脂肪肝/临床诊断/维生素/抗氧化Key words
liver disease/fats/nonalcoholic fatty liver disease/clinical diagnosis/vitamin/anti-oxidant分类
医药卫生引用本文复制引用
余利,冉莉,喻瑾,汪小兰,郎和东,周敏,王斌,易龙,糜漫天..非酒精性脂肪性肝病患者血清维生素与抗氧化指标检测分析[J].重庆医学,2018,47(10):1347-1350,4.基金项目
国家高技术研究发展计划(863计划)课题(2014AA022301,2014AA022302). （863计划）
