重庆医学2018，Vol.47Issue(10)：1351-1353,3.DOI:10.3969/j.issn.1671-8348.2018.10.015
雾化吸入米力农在慢性阻塞性肺疾病合并肺动脉高压患者术中的应用研究
Research on intraoperative application of milrinone nebulized inhalation in patients with chronic obstructive pulmonary disease complicating pulmonary arterial hypertension
摘要
Abstract
Objective To evaluate the clinical effect of milrinone nebulized inhalation for improving intraoperative cardiac function and pulmonary arterial pressure in the patients with chronic obstructive pulmonary disease (COPD) complicating pulmonary hypertension (PH).Methods Forty-four surgical patients with COPD complicating PH in the Chongqing Municipal Medical Emergency Center from June 2015 to June 2016 were chosen,including 23 cases of thoracic surgery,13 cases of abdominal surgery and 8 cases of lower extremity fracture surgery.The patients were divided into the control group and treatment group,22 cases in each group.The control group received the routine comprehensive treatment.In addition receiving the conventional comprehensive treatment,milrinone nebulized inhalation in the treatment group was given before general anesthesia.Both of the two groups were imbedded with floating catheter in the right internal jugular vein for detecting the clinical indexes:cardiac output (CO),pulmonary artery systolic pressure (PASP),pulmonary artery mean pressure (PAMP) and pulmonary capillary wedge pressure (PCWP).Results Compared with before treatment,CO after treatment in the treatment group was significantly increased (P＜0.05),PASP,PAMP and PCWP after treatment in the treatment group were significantly decreased(P＜0.05).CO,PASP,PAMP and PCWP in the control group had no statistical difference between before and after treatment,the difference was not statistically significant (P＞0.05).Conclusion Intraoperative milrinone nebulized inhalation in the patients with COPD complicating PH can effectively improve the patient's cardiopulmonary function.关键词
米力农/高血压,肺性/雾化吸入/肺动脉高压/全身麻醉Key words
milrinone/hypertension, pulmonary/nebulized inhalation/pulmonary hypertension/general anesthesia分类
医药卫生引用本文复制引用
赵卫兵,陈菲,彭方毅,姜海蓉,彭方亮..雾化吸入米力农在慢性阻塞性肺疾病合并肺动脉高压患者术中的应用研究[J].重庆医学,2018,47(10):1351-1353,3.基金项目
重庆市卫生和计划生育委员会基金资助项目(2015ZBXM088). （2015ZBXM088）
