大学化学2018，Vol.33Issue(3)：48-54,7.DOI:10.3866/PKU.DXHX201709018
生物正交反应法制备含有赖氨酸翻译后修饰类似物的蛋白质
Applying Bioorthogonal Reactions to the Synthesis of Proteins Containing Lysine Post-Translational Modification Mimics
王志鹏 1程农壹 2李曼 3王田1
作者信息
- 1. Department of Chemistry, Texas A&M University, College Station, Texas 77840, USA
- 2. 清华大学化学系,北京 100084
- 3. Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
- 折叠
摘要
Abstract
As an important topic in epigenetic research, post-translational modifications (PTMs) have been drawing more and more attention recently. With the increasing number of novel PTMs discovered, they have been found widely existing in human proteome. Although cell biology research showed their significant roles in the regulation of chromatin structure and gene transcription functions, the more detailed functions are remaining unclear. For further biology research, chemical biologists need to develop synthetic strategies for the proteins with specific PTMs at desired sites. This manuscript will introduce the application of bioorthogonal reactions to protein chemistry for the incorporation of lysine PTMs. We hope it can contribute to the research and education ongoing.关键词
翻译后修饰/生物正交反应/蛋白质组Key words
Post-translational modification/Bioorthogonal reaction/Proteome分类
社会科学引用本文复制引用
王志鹏,程农壹,李曼,王田..生物正交反应法制备含有赖氨酸翻译后修饰类似物的蛋白质[J].大学化学,2018,33(3):48-54,7.
