海南医学院学报2018，Vol.24Issue(5)：608-611,615,5.DOI:10.13210/j.cnki.jhmu.20180223.001
甲泼尼龙联合孟鲁斯特对复发性过敏性紫癜患儿免疫功能、细胞因子的影响
Effects of methylprednisolone combined with montelukast on immune function and cytokines in children with recurrent Henoch-Schonlein purpura
摘要
Abstract
Objective:To study the effects of methylprednisolone combined with montelukast on immune function and cytokines in children with recurrent Henoch-Schonlein purpura.Methods:Children who were diagnosed with recurrent Henoch-Schonlein purpura in Zigong Third People's Hospital between September 2015 and August 2017 were selected as the research subjects and randomly divided into the intervention group who received methylprednisolone combined with montelukast therapy and the control group who received hydrocortisone therapy.The levels of Th1/Th2 and Th17/Treg immunity indexes in periph-eral blood as well as cytokines in serum were measured before treatment as well as 4 and 8 weeks after treatment.Results:4 weeks and 8 weeks after treatment,Th1 and Treg cell contents as well as T-bet and FoxP3 mRNA expression in peripheral blood of both groups of patients were significantly higher than those before treatment whereas Th 2 and Th17 cell contents as well as GATA-3 and RORγt mRNA expression in peripheral blood and NF-κB,OPN,IL-33,MK and HMGB1 contents in ser-um were significantly lower than those before treatment(P< 0.05),and Th1 and Treg cell contents as well as T-bet and FoxP3 mRNA expression in peripheral blood of intervention group were significantly higher than those of control group where-as Th2 and Th17 cell contents as well as GATA-3 and RORγt mRNA expression in peripheral blood and NF-κB,OPN,IL-33, MK and HMGB1 contents in serum were significantly lower than those of control group(P<0.05).Conclusion:methylpred-nisolone combined with montelukast treatment of recurrent Henoch-Schonlein purpura can regulate the immune function and in-hibit the cytokine secretion.关键词
过敏性紫癜/甲泼尼龙/孟鲁斯特/免疫功能/细胞因子Key words
Henoch-Schonlein purpura/methylprednisolone/montelukast/immune function/cytokine分类
医药卫生引用本文复制引用
代静..甲泼尼龙联合孟鲁斯特对复发性过敏性紫癜患儿免疫功能、细胞因子的影响[J].海南医学院学报,2018,24(5):608-611,615,5.基金项目
自贡市科技局课题项目(J2015029) （J2015029）
It is supported by Zigong Science and Technology Bureau Project(J2015029). （J2015029）
