海南医学院学报2018，Vol.24Issue(5)：616-619,4.DOI:10.13210/j.cnki.jhmu.20180227.005
重组人干扰素α2b雾化对手足口病患儿血清细胞因子及外周血免疫细胞的影响
Effects of recombinant human interferon α2b atomization on serum cytokines and peripheral blood immune cells in children with HFMD
摘要
Abstract
Objective:To study the effects of recombinant human interferon α2b atomization on serum cytokines and pe-ripheral blood immune cells in children with HFMD.Methods:Children who were diagnosed with hand-foot-and-mouth disease in Tongji Hospital Tongji Medical College Huazhong University of Science & Technology between June 2014 and August 2017 were selected as the research subjects and randomly divided into the interferon α2b group who accepted human recombi-nant interferon α2b atomization combined with conventional symptomatic treatment and the control group who accepted conven-tional symptomatic treatment.The contents of cytokines in serum and the contents of immune cells in peripheral blood were de-termined before treatment as well as 3 days and 5 days after treatment.Results:3 days and 5 days after treatment,IL-6,IL-13,TNF-α,CRP,MCP-1,VCAM-1 and ICAM-1 contents in serum as well as the contents of CD19+CD24highCD27+B cells in peripheral blood of both groups of children with were significantly lower than those before treatment whereas the contents of CD3+CD4+T cells,CD3+CD8+T cells and CD16+CD56+NK cells in peripheral blood were higher than those before treatment (P<0.05),and IL-6,IL-13,TNF-α,CRP,MCP-1,VCAM-1 and ICAM-1 contents in serum as well as the contents of CD19+CD24highCD27+B cells in peripheral blood of interferon α2b group were significantly lower than those of control group whereas the contents of CD3+CD4+T cells,CD3+CD8+T cells and CD16+CD56+NK cells in peripheral blood were higher than those of control group(P<0.05).Conclusion:Recombinant human interferon α2b atomization treatment of HFMD can reduce the inflammatory response and improve the immune response.Key words:关键词
手足口病/干扰素α2b/炎症反应/免疫应答Key words
Hand-foot-and-mouth disease/Interferon α2b/Inflammatory response/Immune response分类
医药卫生引用本文复制引用
张文迪,余肖,蔡在胜..重组人干扰素α2b雾化对手足口病患儿血清细胞因子及外周血免疫细胞的影响[J].海南医学院学报,2018,24(5):616-619,4.基金项目
国家重点基础研究发展项目(973计划)(2005CB5225007) （973计划）
卫生部临床学科重点项目2010-2012 （）
"十一五"国家科技支撑计划(2006BAI05A07) （2006BAI05A07）
This study was supported by National Key Basic Research and Development Project(973 Project)[Grant No.2005CB5225007] （973 Project）
Key Project for Clinical Discipline of Ministry of Health between 2010 and 2012 （）
National Science and Technology Support Program of"11th Five-Year Plan"(Grant No.2006BA I05A07). （Grant No.2006BA I05A07）
