华东师范大学学报（自然科学版）Issue(2)：125-130,159,7.DOI:10.3969/j.issn.1000-5641.2018.02.013
蛋白酶体激活因子REGγ的肿瘤相关靶蛋白研究进展
Research progress of the target proteins by proteasome activator REGγ in human cancers
摘要
Abstract
The proteasome activator REGγ,which is a member of REG (11 S) proteasome activator family,can stimulate the proteolytic activity of the 20 S core proteasome to degrade proteins independent of ubiquitination and ATP.In recent years,more and more studies show that REGγ is dysregulated in various human cancers and closely related to the oncogenesis and development of cancers.The potential mechanism by which REGγ exerts its role in cancer development is degradation of various target proteins.We now review the target proteins of REGγ in human cancers in order to further understand the mechanism by which REGγ exerts its role in cancer development,and to uncover the potential of REGγto serve as a new marker for diagnosis and a novel target for treatment in human cancers.关键词
REGγ/肿瘤/靶蛋白Key words
REGγ/cancer/target proteins分类
数理科学引用本文复制引用
陈少军,李晓涛,郑军华..蛋白酶体激活因子REGγ的肿瘤相关靶蛋白研究进展[J].华东师范大学学报（自然科学版）,2018,(2):125-130,159,7.基金项目
国家自然科学基金(81602216) （81602216）
