摘要
Abstract
Objective To observe the effect of paroxetine combined with olanzapine on S100B,S100β and Repetin in schizophrenic patients.Methods A total of 80 patients with severe acute pancreatitis in our hospital from February 2016 to April 2017 were randomly divided into control group and study group,with 40 cases in each group.The control group was treated with olanzapine alonea,and the study group was treated with paroxetine combined with olanzapine,the treatment was lasted for 4 weeks in two groups.The therapeutic effect,PANSS score,serum S100B,S100β,Repetin and adverse reactions between the two groups were observed.Results After treatment,the total response rate of the study group was significantly higher than that of the control group (x2 =4.51,P =0.04).The reduction in PANSS scores in the study group was significantly better than in the control group (F =2.98,P =0.02);Serological examination showed that S100B,S100β levels were significantly lower,and Repetin levels was significantly higher than that in the control group,than the control group;The difference in adverse reactions between the two groups showed no statistically significant difference (P ＞ 0.05).Conclusion The combination of paroxetine and olanzapine has significant effect for schizophrenic patients.PANSS score is significantly decreased,levels of serum S100B and S100β expression are significantly decreased,Repetin level is increased significantly,and it has higher safety.So it is worth promoting in clinic.关键词
帕罗西汀/奥氮平/精神分裂症/神经功能性因子/神经生化标志物/中间丝相关蛋白Key words
paroxetine/olanzapine/schizophrenia/neurofunctional factors/neurobiochemical markers/intermediate filamentous protein分类
医药卫生
