实用临床医药杂志2018，Vol.22Issue(7)：35-37,41,4.DOI:10.7619/jcmp.201807009
银杏叶提取物联合氯吡格雷治疗缺血性脑卒中的临床疗效与安全性
Clinical efficacy and safety of ginkgo biloba extract combined with clopidogrel in the treatment of patients with ischemic stroke
张连军 1莫鸣 1徐冬梅1
作者信息
- 1. 江苏省荣军医院药剂科,江苏无锡,214035
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of ginkgo biloba extract combined with clopidogrel in the treatment of patients with ischemic stroke.Methods Totally 80 patients with ischemic stroke were randomly divided into observation group and control group,40 cases in each group.Both groups received routine therapies such as lipid-lowering,antihypertensive and microcirculation improvement.The control group received clopidogrel 75 mg for once per day.The observation group received 2 tablets of ginkgo tablet,three times per day.Clinical efficacy,blood rheology indexes,blood pressure,NIHSS score,ADL score,coagulation indexes,fibrinolysis indexes and adverse reactions were compared between two groups.Results The total effective rate and the scores of NIHSS and ADL in the observation group were significantly better than those in the control group (P ＜ 0.05).The blood rheology indexes,blood pressure,coagulation and fibrinolysis indexes of the two groups significantly improved after treatment (P ＜ 0.05),and the indexes in the observation group improved more significantly when compared with control group (P ＜ 0.05).There was no significant difference in the incidence rate of adverse reactions between two groups (P ＞ 0.05).Conclusion Ginkgo biloba extract combined with clopidogrel is effective in the treatment of patients with ischemic stroke,and it has a good synergistic effect.关键词
银杏叶提取物/缺血性脑卒中/氯吡格雷/临床疗效/安全性Key words
ginkgo biloba extract/ischemic stroke/clopidogrel/clinical efficacy/safety分类
医药卫生引用本文复制引用
张连军,莫鸣,徐冬梅..银杏叶提取物联合氯吡格雷治疗缺血性脑卒中的临床疗效与安全性[J].实用临床医药杂志,2018,22(7):35-37,41,4.
