实用临床医药杂志2018，Vol.22Issue(7)：120-122,3.DOI:10.7619/jcmp.201807034
2型糖尿病患者血清游离脂肪酸水平与胰岛素抵抗的关系
Relationship between serum free fatty acids level and insulin resistance in patients with type 2 diabetes mellitus
郁淼 1张莉 1秦兵 1胡道军1
作者信息
- 1. 上海交通大学医学院附属新华医院崇明分院检验科,上海,202150
- 折叠
摘要
Abstract
Objective To investigate the relationship between serum free fatty acids (FFA) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).Methods Totally 106 T2DM patients were selected as observation group,and 106 healthy people were selected as control group.Body mass index (BMI),FPG,FFA,HbAlc,TG,TC and HOMA-IR were compared between two groups.According to the blood glucose level,the T2DM patients were divided into good control group (n =56) and bad control group (n =50),and the FFA and HOMA-IR were compared two groups.Correlation between serum FFA and HOMA-IR in patients with T2DM was analyzed.Results In the observation group,BMI,FPG,FFA,HbA1 C,TC,TG and HOMA-IR were significantly higher than the control group (P ＜ 0.05).FFA and HOMA-IR in bad control group were significantly higher than the good control group (P ＜ 0.05).Correlation analysis showed that serum FFA was positively correlated with HOMA-IR level in T2DM patients (r =0.621,P ＜ 0.05).Conclusion Serum free fatty acids level is closely related to insulin resistance in patients with T2DM,which can reflect the blood glucose control level.关键词
2型糖尿病/游离脂肪酸/胰岛素抵抗/相关性Key words
type 2 diabetes mellitus/free fatty acids/insulin resistance/correlation分类
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郁淼,张莉,秦兵,胡道军..2型糖尿病患者血清游离脂肪酸水平与胰岛素抵抗的关系[J].实用临床医药杂志,2018,22(7):120-122,3.
