检验医学与临床2018，Vol.15Issue(3)：293-296,300,5.DOI:10.3969/j.issn.1672-9455.2018.03.002
胱抑素C及其基因多态性与广西地区壮族人群冠心病的相关性
Association of cystatin C and its gene polymorphism with coronary heart disease in Guangxi Zhuang population
摘要
Abstract
Objective To investigate the association between the levels of cystatin C (Cys-C) and its +148 G/A,+ 73 A/G and-82 G/C loci in Guangxi Zhuang ethnic groups with CHD.Methods The levels of serum Cys-C in CHD group,CHD group,Zhuang healthy group and Han healthy group were detected by immune turbidimetry.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the polymorphisms of +148,+73 and-82 at Cys-C locus,and the clinical data of each group was collected.Results Compared with the two healthy groups,the clinical data and serum Cys-C levels in the two CHD groups were different,the differences were statistically significant (P＜0.05).There was a positive correlation between Cys-C levels and creatinine (Cr) levels in the 4 groups (r=0.597,P＜0.05).The frequency distribution of Cys-C gene + 73 locus in two CHD groups was different from that in healthy group,the differences were statistically significant (P＜0.05).The level of Cys-C in patients of CHD with GG type at Cys-C +73 site was lower than those of AG type and AA type,the difference was statistically significant (P＜0.05).There was no significant difference in Cys-C level between AG type and AA type (P＞0.05).Conclusion Impaired renal function masks Cys-C low levels due to Cys-C+ 73 gene polymorphisms.The Cys-C low level caused by Cys-C+ 73 gene polymorphism may be a risk factor for CHD patients in Zhuang and Han ethnic groups in Guangxi.关键词
胱抑素C/基因多态性/冠心病Key words
cystatin C/polymorphism/coronary heart disease分类
医药卫生引用本文复制引用
朱旭,郑利平,杨兰,陆俊佳..胱抑素C及其基因多态性与广西地区壮族人群冠心病的相关性[J].检验医学与临床,2018,15(3):293-296,300,5.基金项目
广西壮族自治区南宁市科技课题资助项目(20123137). （20123137）
