摘要
Abstract
Objective To investigate the relationship between GP73,CEA,AFP-L3 and HBV-DNA,and their diagnostic value in the classification in patients with liver cirrhosis.Methods A total of 72 cases of hepatitis B were selected from August 2015 to August 2016 year in our hospital as the research objects,which 40 cases of LC,32 cases of PHC,and 34 cases of liver function examination surface antibody positive healthy were selected as the controls.DNA HBV was detected by FQ-PCR method,and AFP-L3,GP73 and CEA levels in all subjects were detected by ELISA.Results LC group of serum AFP-L3,GP73,CEA were significantly higher than the control group,the differences were statistically significant (P＜0.05),PHC group of serum AFP-L3,GP73,CEA levels were significantly higher than those in group LC (P＜0.05);The levels of serum AFP-L3,GP73 and CEA in the negative group were significantly higher than those in the control group (P＜ 0.05),and increased with the increase of DNA HBV load (P＜0.05);The levels of serum AFP-L3,GP73 and CEA increased with the increase of Child-Pugh (P＜0.05);The serum levels of AFP-L3,GP73,CEA and DNA HBV were positively correlated (rs =0.582,0.521,0.630,P＜0.05).Conclusion The serum levels of AFP-L3,GP73,CEA are closely related to the persistent infection of DNA HBV,which may be used as serum markers for the diagnosis of LC and the monitoring of disease progression.关键词
肝硬化/乙型肝炎病毒/血清甲胎蛋白L3/高尔基体蛋白-73/癌胚抗原Key words
liver cirrhosis/hepatitis B virus/alpha-fetal protein L3/golgi protein 73/carcino-embryonic antigen分类
医药卫生
