摘要
Abstract
Objective To investigate the effect of accelerated fractionation (CAF) and capecitabine on postoperative recurrence of rectal cancer and its influence on immune cells.Methods From May 2014 to September 2016,71 patients with recurrent rectal cancer in Kailuan General Hospital of Hebei,Tangshan City province were selected.All patients were treated with CAF synchronous capecitabine and radiotherapy,using CAF,1.2Gy/F,two times a day,each interval of 6 h,capecitabine 850 ms/m2,once a day,oral two times.Two cycles of chemotherapy after radiotherapy.Results Totally 71 cases of patients with severe diarrhea stopped chemotherapy,withdrew from the study.And 69 cases of patients with complete remission in 11 cases (15.94％) and partial in 42 cases (60.87％),12 cases (17.39％) in a stable condition,the lesion progress in 4 cases (5.80％),the clinical total effective rate was 76.81％.The 1-year survival rate was 84.03％ and the local control rate was 59.64％.The 2-year survival rate was 62.32％ and the local control rate was 42.64％.There was no significant difference between T lymphocyte and chemotherapy before and after chemotherapy in the study (P＞0.05).This study 69 patients of liver injury in 2 cases (2.90％),renal damage in 1 case (1.49％),gastrointestinal tract reaction,21 cases (30.43％),peripheral neuritis,8 cases (11.59％).All adverse reactions were less than grade Ⅳ,which could be tolerated.Conclusion Accelerated fractionation and capecitabine after radiotherapy for rectal cancer can improve the local control rate,prolong the survival time,and have little influence on the level of T lymphocyte.The toxicity is mild and the safety is better.关键词
加速超分割/卡培他滨/直肠癌Key words
accelerated fractionation/capecitabine/rectal cancer分类
医药卫生
