检验医学与临床2018，Vol.15Issue(8)：1057-1060,4.DOI:10.3969/j.issn.1672-9455.2018.08.001
血清S100β蛋白水平医学参考区间的建立
Establishment of the reference interval of serum protein S100βlevel
摘要
Abstract
Objective To establish the reference interval of serum level of protein S 100β(S100β),based on local healthy population,according to CLSI C28-A3,developed through the Clinical and Laboratory Standards Institute consensus process.Methods A total of 207 healthy subjects were enrolled,Roche Combas e601 ana-lyzer and Elecsys S100 kits were used,for the detection of serum S100β level.The non-parametric and para-metric procedures were used for the ascertainment of reference interval.Results Neither significant difference in serum S100β level between male and female(P>0.05),nor significant correlation between S100β level and age was observed(P>0.05),so data of different genders and ages were combined and analyzed as a whole;the observed S100β values were highly skewed,but after log transform,it followed normal distribution;estimation of reference interval:based on parametric method,the 97.5 percentile was 0.126 6(original observed values) and 0.126 5 μg/L(log transform),and based on the non-parametric method,the 97.5 percentile was 0.125 8 (original observed values)and 0.125 7 μg/L(log transform),respectively.Conclusion T he establishment of reference interval of serum S100β protein level,has laid a foundation for its routinely clinical use.关键词
S100β蛋白/参考区间/颅脑损伤Key words
protein S100β/reference interval/brain lesion分类
医药卫生引用本文复制引用
谭延国,刘晴,王晓宁,田野,古媛,车冬丽,林红,张岩,李卓敏,王新宇,亢涛,王志阳,董一红,李佩,郑芳芳,聂秋燕..血清S100β蛋白水平医学参考区间的建立[J].检验医学与临床,2018,15(8):1057-1060,4.基金项目
首都临床特色应用研究(吴阶平)基金资助项目(Z141107006614008). （吴阶平）
