检验医学与临床2018，Vol.15Issue(8)：1136-1139,4.DOI:10.3969/j.issn.1672-9455.2018.08.025
卵巢癌转移相关基因异常表达的相关性研究
Correlation study of abnormal expression of metastatic genes in ovarian cancer
罗晓莲 1秦风雪 1林珍 1李永良2
作者信息
- 1. 青海省交通医院妇产科,西宁810001
- 2. 青海省交通医院普外科,西宁810001
- 折叠
摘要
Abstract
Objective Based on relevant database data analysis,to explore the correlation of the abnormal expression of ovarian cancer-related gene and ovarian cancer.Methods Based on some data sets of GEO in the NCBI database,to perform express analysis,survival analysis and correlation analysis.Results The results showed that Snail1 and Twist1 in ovarian cancer patients significantly higher expressed.The high expression of Snai1 and Twist1 could lead to a significant reduction in overall survival and disease-free survival in ovarian cancer patients(Snai1,P<0.05,Twist1,P<0.05).Snai1 and Twist1 had significant high expression in ovari-an cancer after drug therapy(Snai1,P<0.05,Twist1,P<0.05).Snai1 and Twist1 positively correlated in o-varian cancer(r=0.452,P<0.01).Conclusion T he abnormal expression of ovarian cancer metastasis-related genes associated with the development of ovarian cancer patients and had effection on their drug tolerance and prognosis.关键词
卵巢癌/基因表达谱/雷替曲塞/耐药/预后Key words
ovarian cancer/gene expression profile/raltitrexed/drug resistance/prognosis分类
医药卫生引用本文复制引用
罗晓莲,秦风雪,林珍,李永良..卵巢癌转移相关基因异常表达的相关性研究[J].检验医学与临床,2018,15(8):1136-1139,4.
