林产化学与工业2018，Vol.38Issue(2)：105-111,7.DOI:10.3969/j.issn.0253-2417.2018.02.014
大黄酸衍生物的合成及其抑菌活性研究
Synthesis and Antibacterial Activity of Derivatives of Rhein
摘要
Abstract
Based on carboxyl amidation of rhein(1),a series of derivatives of rhein were synthesized by structure modification of C7 of anthraquinone mother nucleus. And the antibacterial activity and structure-activity relationship of the derivatives were preliminary discussed. The derivatives of rhein were respectively rhein piperidine amide(2), 7-hydroxymethyl-rhein piperidine amide(3),7-bromomethyl-rhein piperidine amide(4),7-(4-morpholino)methyl-rhein piperidine amide(5a), 7-(pyrrolidin-1-yl)methyl-rhein piperidine amide(5b), 7-(1-methyl-4-piperazinyl)methyl-rhein piperidine amide(5c). The structures of the compounds were characterized by IR, 1H NMR, 13C NMR,MS. The minimal inhibitory concentrations(MIC) of the compounds obtained were tested and the MIC of compounds 5a and 5b against E.coli reached 0.78 and 0.39 mg/L respectively. Their antibacterial activity were stronger than that of rhein(MIC 3.13 mg/L) obviously,even stronger than that of the kanamycin(MIC 1.56 mg/L);and the MIC of compound 5a against S. aureus reached 1.56 mg/L, which was similar to that of rhein. The preliminary analysis of structure effective relationship showed that if none replace heterocyclic groups were introduced into substituent of C7 of the mother nucleus,the antibaterial activity on E.coli would be stronger.关键词
大黄酸/结构修饰/抑菌活性/初步构效关系Key words
rhein/structure modification/antibacterial activity/preliminary structure-activity relationship分类
化学化工引用本文复制引用
王兴达,李蕾,韩泳平..大黄酸衍生物的合成及其抑菌活性研究[J].林产化学与工业,2018,38(2):105-111,7.基金项目
"十二五"国家科技支撑计划资助(2012BAI27B07) （2012BAI27B07）
西南民族大学研究生创新型科研项目硕士重点项目(CX2017SZ082) （CX2017SZ082）
