临床神经外科杂志2018，Vol.15Issue(2)：95-101,7.DOI:10.3969/j.issn.1672-7770.2018.02.004
帕金森病患者运动迟缓症状的定量评估
Quantitative assessment of bradykinesia in patients with Parkinson's disease
摘要
Abstract
Objective The aim of this study is to verify the feasibility and effectiveness of quantitative wearable assessment system in evaluating the symptoms of bradykinesia in patient with Parkinson's disease,and to explore the characteristics and clinical significance of quantitative indices of bradykinesia.Methods The subjects included a healthy control group and a drug therapy group. The healthy control group consisted of 15 healthy elderly people whose age and sex were matched to the drug therapy group.In the drug therapy group,11 patients with Parkinson's disease were recruited according to the Diagnostic criteria for Parkinson's disease in China(2016).The levodopa challenge tests were performed,and the drug therapy group was in two states:medication-on and medication-off state.All PD patients were assessed with the Unified Parkinson's Disease Rating Scale(UPDRS). Quantitative wearable assessment system was used to record the motion data in two groups of three paradigm maneuvers:wrist-turning,foot-tapping and walking back and forth in 10 meters.Amplitude, frequency and other motion indicators were extracted and compared among groups.Then the correlation analysis was carried out between motion data and the subitems or combination of subitems of UPDRS Ⅲ.Results There were significant differences in wrist-turning amplitude,stride angle and turning time among the healthy control group and the drug therapy group in medication-on and medication-off state(P<0.05 -0.01).There was a positive correlation between the turning time and the scores of gait(Ⅲ29),axial symptom(Ⅲ18 -19,27 -31),bradykinesia plus axial symptom(Ⅲ18,19,23-31)of UPDRSⅢ(r=0.824,P=0.002;r=0.779,P=0.005;r=0.673, P=0.023).Conclusion The quantitative wearable assessment system can be used to measure bradykinesia symptom in Parkinson's disease,and to evaluate the effect of drug therapy on bradykinesia symptom in patients with Parkinson's disease,which provides a new method for accurate management of Parkinson's disease.关键词
帕金森病/运动迟缓/运动功能定量评估/可穿戴定量评估系统Key words
Parkinson's disease/bradykinesia/quantitative assessment of motor function/quantitative wearable assessment system分类
医药卫生引用本文复制引用
蒋顶,龚大伟,罗回春,沈天毓,白启帆,王守岩,章文斌..帕金森病患者运动迟缓症状的定量评估[J].临床神经外科杂志,2018,15(2):95-101,7.基金项目
江苏省重点研发计划(社会发展)基金(BE2016614) （社会发展）
南京市卫计委重点项目(ZKX15032) （ZKX15032）
南京市医学科技发展资金资助项目(201507034) （201507034）
