临床神经外科杂志2018，Vol.15Issue(2)：124-127,133,5.DOI:10.3969/j.issn.1672-7770.2018.02.010
促红细胞生成素对破裂颅内动脉瘤患者的神经保护作用研究
Efficacy of erythropoietin on postoperative cerebral ischemia in patients after surgery for ruptured intracranial aneurysm
摘要
Abstract
Objective To investigate the protective mechanism of erythropoietin(EPO)on neurological deficits caused by ruptured aneurysms.Methods A total of 180 patients with ruptured intracranial aneurysms were selected,meanwhile the control group and the treatment group were randomly divided with 90 cases in each group.The treatment group was given a hypodermic injection of EPO from the first day after the operation for three days,while the control group was replaced by normal saline,and the remaining treatment was the same.The NIHSS scores of the two groups were compared on admission,7 d,14 d,21 d,28 d and 35 d after the admission.And the changes of specific enolase(NSE)and interleukin 6(IL-6)in cerebrospinal fluid(CSF)of the two groups of patients after 1 d,4 d,7 d,10 d,and 14 d were analyzed.Results The NIHSS scores of 21 d,28 d and 35 d after operation in the treatment group were 8.8 +1.6,8.2 +1.5 and 7.2 +1.3, respectively,while the scores of control group were 11.4 +2.1,10.5 +2 and 10.3 +2 respectively.The two groups were compared(P <0.05),and the difference was statistically significant.Through the comparison of the percentage reduction of cerebral ischemia volume between the two groups,the reduction rates of 21 d,28 d and 35 d cerebral ischemia volume in the treatment group were(20.6 ±3.7)%,(29.1 ±6)%,(31.7 ±5.2)%,which were significantly higher than that in the control group(15.7 ±3)%,(19 ±3.4)%,(19.1 ±3.0)%.The difference between the two groups was statistically significant(P<0.05).The content of NSE and IL-6 in cerebrospinal fluid (CSF)in the treatment group was lower than that of the control group on 7 d,10 d and 14 d after operation,and the difference between the two groups was statistically significant(P <0.05). Conclusion EPO can promote the recovery of the progressive function of ruptured aneurysm,and it is worthy of clinical application.关键词
颅内动脉瘤/促红细胞生成素/术后并发症/脑缺血Key words
ruptured aneurysm/erythropoietin/postopoietin of intracranial aneurysm/cerebral ischemia分类
医药卫生引用本文复制引用
宋纪宁,薛振生,杨利辉,高海晓,石素真,郭雪钗,尹保强,祖兴旺,李鑫,曹明善..促红细胞生成素对破裂颅内动脉瘤患者的神经保护作用研究[J].临床神经外科杂志,2018,15(2):124-127,133,5.基金项目
邢台市科技计划项目(2016ZC281) （2016ZC281）
