中国临床保健杂志2018，Vol.21Issue(2)：172-175,4.DOI:10.3969/J.issn.1672-6790.2018.02.008
宫颈癌患者T淋巴细胞亚群与自然杀伤细胞水平和病情的相关性
Relationship between T Lymphocyte subsets and NK cells and disease condition of patients with cervical cancer
摘要
Abstract
Objective To investigate the relationship between T lymphocyte subsets and NK cells and disease condition of patients with cervical cancer.Methods A total of 226 patients with cervical cancer in our hospital were di-vided into stage Ⅰgroup(52 cases),stage Ⅱgroup(63 cases),stage Ⅲgroup(57 cases)and stage Ⅳ group(ca-ses)according to their clinical stage,and 60 cases of healthy women in the same period were selected as control group. The T lymphocyte subsets(CD3 +,CD3 +CD4 +,CD3 +CD8 +,CD3 +CD4 +/CD3 +CD8 +)and NK cells(CD16 +CD56 +)of each group were detected by Flow cytometry and compared.Results The CD3 +level of stage Ⅱ group, stage Ⅲgroup,stage Ⅳgroup were significantly lower than those of control and stage Ⅰgroup(P<0.05),and CD3 +level decreased with the increase of stage(P<0.05).The CD3 +CD4 +,CD3 +CD4+/CD3 +CD8 +levels of stage Ⅰgroup,stageⅡgroup,stageⅢgroup,stageⅣgroup were significantly lower than those of control group(P<0.05),and CD3 +CD4 +,CD3+CD4 +/CD3 +CD8 +levels decreased with the increase of stage(P<0.05).The CD3 +CD8 +levels of stageⅡgroup,stageⅢgroup,stageⅣgroup were significantly higher than those of control and stage Ⅰgroup(P<0.05),and CD3 +level increased with the increase of stage(P<0.05).The CD16 +CD56 +levels of stage Ⅰ group, stage Ⅱgroup,stage Ⅲ group,stage Ⅳ group were significantly lower than those of control group(P<0.05),and CD16 +CD56 +levels decreased with the increase of stage(P<0.05).The clinical stage of cervical cancer was nega-tively correlated with CD3 +,CD3 +CD4 +,CD3 +CD4 +/CD3 +CD56 +and CD56 +CD56 +(P<0.01),and positively correlated with CD3 +CD8 +(P<0.01).Conclusion T lymphocyte subsets and NK cell levels could reflect the cellular immune function of cervical cancer patients,and the clinical stage of cervical cancer is later,the cellular immune func-tion is worse.关键词
宫颈肿瘤/T淋巴细胞亚群/自然杀伤T细胞/免疫,细胞Key words
Uterine cervical neoplasms/T-lymphocyte subsets/Natural killer T-cells/Immunity,cellular分类
医药卫生引用本文复制引用
王祝荣,杨霞,何佳萌,王丽,胡晓美..宫颈癌患者T淋巴细胞亚群与自然杀伤细胞水平和病情的相关性[J].中国临床保健杂志,2018,21(2):172-175,4.基金项目
江苏省自然基金科学资助项目(BK20161387) （BK20161387）
