中国临床保健杂志2018，Vol.21Issue(2)：175-178,4.DOI:10.3969/J.issn.1672-6790.2018.02.009
冠心病合并高血压患者CYP2C19基因多态性与氯吡格雷抵抗的研究
Study on CYP2C19 gene polymorphism and clopidogrel resistance in patients with coronary heart disease com-plicated with hypertension
摘要
Abstract
Objective To study the distribution of CYP2C19 gene polymorphism and the relationship between different genotypes and clopidogrel resistance(CR)in patients with coronary heart disease and hypertension.Methods One hundred and four patients with coronary heart disease were divided into two groups:hypertension group and non-hy-pertension group.All patients were treated with clopidogrel 75mg and aspirin 100mg antiplatelet therapy.CYP2C19 geno-type was detected by by gene chip method,and the platelet aggregation rate were detected on the next day and 5 days af-ter take medicine.The distribution of different genotypes of CYP 2C19 and the clopidogrel resistance were observed.Re-sults There was no significant difference in the metabolic genotype of CYP 2C19 between the two groups(P=0.135), and there was no significant differences between the two groups in the incidence of CR.The incidence of CR was in-creased in the slow and middle metabolizing group(P<0.05),and the incidence of CR was significantly increased.Lo-gistic multivariate regression analysis showed that the CYP 2C19 gene was an independent predictor of CR in patients with coronary heart disease and hypertension.Conclusions The polymorphisms of CYP2C19 gene and the incidence of CR in patients with coronary heart disease are not associated with hypertension,but CR and CYP2C19 gene polymor-phisms are significantly correlated.关键词
冠心病/高血压/多态性,单核苷酸/噻吩吡啶Key words
Coronary disease/Hypertension/Polymorphism,single nucleotide/Thienopyridines分类
医药卫生引用本文复制引用
沈伟,赵韧,宋兵,曹中,王邦宁..冠心病合并高血压患者CYP2C19基因多态性与氯吡格雷抵抗的研究[J].中国临床保健杂志,2018,21(2):175-178,4.基金项目
安徽省自然科学基金项目(1508085QH164) （1508085QH164）
