中国临床保健杂志2018，Vol.21Issue(2)：214-217,4.DOI:10.3969/J.issn.1672-6790.2018.02.020
复方利血平氨苯蝶啶片治疗原发性高血压的Meta分析
Meta-analysis on the curative effect,safety and cost performance of Compound Rreserpine Triamterene tablets in the treatment of primary hypertention
摘要
Abstract
Objective To evaluate systematically the efficacy,cost performance and safety of Compound Reser-pine Triamterene tablets.Methods The databases of Cochrane Controlled Trials Register /CENTRAL,Pubmed,Biomed Central,CJFD,VIP Database and Wangfang Database were retrieved with computers for collecting randomized controlled trials(RCT)about the treatment of hypertention.The RCT were selected by two researchers independently according to inclusion and exclusion criterions and materials were extracted,checked crossly and given methodological quality evalu-tion.The Meta-analysis was conducted by using RevMan 5.0 software.Results The 22 studies were eligible for inclu-sion.As to the efficacy,there was no statistical significant difference between Compound Anti-Hypertensive Tablets and Calcium antagonists(OR=1.10,95%CI:0.86-1.41,P=0.45).It was effective to slow heart rate by persisting in taking medicine of Anti-hypentensive Tablets(OR=1.25,95%CI:0.42-2.08,P=0.003).For the safety,there was also no statistical significant difference between the research drug and the control(OR=1.13,95%CI:0.82-1.56, P=0.46).Conclusion Based on the current evidences,Compound Anti-Hypertensive Tablets appear to have the same effect as calcium antagonists without more adverse events.关键词
高血压/氢氯噻嗪/氨苯蝶啶/利血平/肼苯哒嗪/钙通道阻滞药/Meta分析Key words
Hypertension/Hydrochlorothiazide/Triamterene/Reserpine/Hydralazine/Calcium channel block-ers/Meta-analysis分类
医药卫生引用本文复制引用
黄荣彩,唐海沁,蒋品,李小鹏..复方利血平氨苯蝶啶片治疗原发性高血压的Meta分析[J].中国临床保健杂志,2018,21(2):214-217,4.基金项目
国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015133) （JDZX2015133）
