中国临床保健杂志2018，Vol.21Issue(2)：234-237,4.DOI:10.3969/J.issn.1672-6790.2018.02.025
大鼠陈旧性心肌梗死中碎裂QRS波与心力衰竭的关系研究
The relationship between fragmented QRS complex and heart failure in rats with remote myocardial infarction
摘要
Abstract
Objective To investigate the relationship between fragmented QRS complex and heart failure in rats with remote myocardial infarction.Methods 60 healthy rats were randomly divided into two groups:the myocardial infarction group(n=30)and the sham group(n=30),the surgery of acute MI induction was performed in the myocar-dial infarction group through the left anterior descending coronary artery ligation,animals in the sham group were subjec-ted to sham surgery,without coronary artery ligation.9-lead electrocardiogram were recorded simultaneously in every rats before surgery and after 20 minutes,4 weeks.The cardiac function parameters were assessed by echocardiographic as -sessment,4 week after surgery.Hematoxylin-eosin staining and masson′s Trichrome staining was used to study histopa-thology of cardiac myocytes and quantification of fibrosis was assessed.Results After 5 min ligation,acute myocardial injury changes occurred such as ST segment arch up elevation,T wave towering in the myocardial infarction group.4 weeks after the elevation of the ST segment of the basic decline,part of the lead can be seen T wave inversion,pathologi-cal Q wave or fragmentation QRS complex.The incidence of fragmented QRS complex in the myocardial infarction group was higher than that in the sham group(P<0.01).Compared with the sham group,the left ventricular end-diastolic di-ameter(LVEDd),left ventricular end-systolic diameter(LVESd)increased(P <0.01),and the ejection fraction (EF)decreased(P<0.01).Hematoxylin-eosin staining in the myocardial infarction group,the number of myocardial cells decreased and the fibrosis was observed.Masson′s Trichrome staining showed the large blue fibrotic area was ob-served in the myocardial infarction group,criss-crossing interspersed in the residual myocardial cells around.Conclusion Fragmentation QRS complex has a high incidence in rats with remote myocardial infarction in rats,which may be related to left ventricular enlargement and the decrease of ejection fraction after anterior myocardial infarction.关键词
心肌梗死/心力衰竭/纤维化/大鼠,Sprague-DawleyKey words
Myocardial Infarction/Heart failure/Fibrosis/Rats,sprague-dawley分类
医药卫生引用本文复制引用
陶长艳,张野,马兰,江昕,陈久红..大鼠陈旧性心肌梗死中碎裂QRS波与心力衰竭的关系研究[J].中国临床保健杂志,2018,21(2):234-237,4.基金项目
安徽省高校省级自然科学研究重大项目(KJ2014Z016) （KJ2014Z016）
安徽医科大学校科研基金研究联合资助项目(2015xkj113) （2015xkj113）
