日用化学工业2018，Vol.48Issue(2)：119-122,4.DOI:10.13218/j.cnki.csdc.2018.02.012
高效液相色谱法测定化妆品中对羟基苯乙酮的含量
Determination of 4-hydroxyacetophenone in cosmetics by high performance liquid chromatography
毛善巧 1李西俊 1周立武1
作者信息
- 1. 珠海伊斯佳科技股份有限公司,广东珠海519000
- 折叠
摘要
Abstract
High performance liquid chromatography method was developed for the determination of 4-hydroxyacetophenone in cosmetics.Method:ZORBAX SB-C18 column (4.6 mm × 250 mm,5 μm),the mobile phase was water,methanol and sodium acetate buffer solution,the flow rate was 1.0 mL/min,the column temperature was 25 ℃,the detection wavelength was 275 nm and the injection volume was 10 μL.4-Hydroxyacetophenone has a good linear relationship in the range of 0.01-0.20 g/L with the correlation coefficient of 0.999 4 (n =5).The limit of detection is 3.37 μg/g.The recovery rates of 4-hydroxyacetophenone in toner,cleanser and moisturizing cream are 100.89％,100.29％ and 100.02％,and the relative standard deviations (RSD) are 1.44％,0.56％ and 1.06％,respectively.关键词
化妆品/高效液相色谱法/对羟基苯乙酮/防腐剂Key words
cosmetics/high performance liquid chromatography/4-hydroxyacetophenone/preservatives分类
化学化工引用本文复制引用
毛善巧,李西俊,周立武..高效液相色谱法测定化妆品中对羟基苯乙酮的含量[J].日用化学工业,2018,48(2):119-122,4.
