摘要
Abstract
BACKGROUND:In recent years,the topical use of antibiotics in periodontal pockets has become a new regimen for the prevention and treatment of peri-implantitis.OBJECTIVE:To analyze the effectiveness of minocycline hydrochloride ointment in the treatment of peri-implantitis.METHODS:Eighty cases of peri-implantitis,38 males and 42 females,aged 20-32 years,were divided into two groups:experimental group (n=40) was given minocycline hydrochloride ointment into the bottom of periodontal pockets,once a week;and control group (n=40) was injected iodine glycerol into the bottom of periodontal pockets,once a week.Meanwhile,patients without peri-implantitis were selected as normal control group (n=40).After 4 weeks of treatment,we detected probing index,bleeding index,plaque index,detection of Prevotella melaninogenica and Streptococcus ora/is in the two groups,and then statistically analyzed the clinical efficacy.RESULTS AND CONCLUSION:(1) Before the treatment,probing index,bleeding index,plaque index,and detection rates of Prevotella melaninogenica and Streptococcus oralis were all higher in the experimental group than the normal control group (P ＜ 0.05),but there was no significant difference between the experimental group and the control group.(2) After 4 weeks of treatment,probing index,bleeding index,plaque index,and detection rates of Prevotella melaninogenica and Streptococcus oralis in the experimental and control groups were significantly lowered (P ＜ 0.05),but still higher than those in the normal control group (P ＜ 0.05).In addition,these indices were also significantly lower in the experimental group than the control group (P ＜ 0.05).(3) The clinical efficiency of the experimental group after treatment was significantly higher than that of the control group (98％ vs.75％,P ＜ 0.05).Taken together,minocycline hydrochloride ointment as an effective treatment for peri-implantitis can inhibit the colonization of Prevotella melaninogenica and Streptococcus oralis.关键词
盐酸米诺环素软膏/疗效/生物材料/种植体周围炎分类
医药卫生
