中国组织工程研究2018，Vol.22Issue(6)：971-978,8.DOI:10.3969/j.issn.2095-4344.0077
羟基磷灰石功能梯度生物材料在硬组织中的应用
Application of hydroxyapatite functional graded biomaterials in human hard tissue replacement
摘要
Abstract
BACKGROUND:Functional graded biomaterials promote the development of human hard tissue replacement.OBJECTIVE:To review the research progress of functional graded biomaterials in human hard tissue replacement.METHODS:The first author retrieved the PubMed and CNKI databases for relevant articles published from January 2010 to April 2017 using the keywords of "functional graded biomaterial,hard tissue replacement implants,preparation methods,performance evaluation,dental implants,osseous tissue" in English and Chinese,respectively.RESULTS AND CONCLUSION:Functional graded biomaterials refer to a kind of heterogeneous composite materials with controllable and programmable gradient properties on account of continuous or quasi-continuous changes in the structure and chemical composition.Hydroxyapatite is the primary choice for the material surface.Serving as an emerging biomaterial,the functional graded biomaterial has unique structure mechanism and excellent properties.It gives full play to the performance advantages of each component and reduces internal stress interface between components.Therefore,the functional graded biomaterial will be an issue of concern in the future because of the optimization of its design,preparation and performance.关键词
功能梯度生物材料/羟基磷灰石/硬组织替代/制备/性能评价/山东省自然科学基金/生物材料分类
医药卫生引用本文复制引用
韦薇,舒婧嫒,王晶,郑丽霞,李璐,王青山..羟基磷灰石功能梯度生物材料在硬组织中的应用[J].中国组织工程研究,2018,22(6):971-978,8.基金项目
山东省医药卫生科技发展计划(2013WS0308) （2013WS0308）
山东省自然科学基金(ZR2013HM044)the Medical and Health Science and Technology Development Plan of Shandong Province,No.2013WS0308 （ZR2013HM044）
the Natural Science Foundation of Shandong Province,No.ZR2013HM044 （）
