新医学2018，Vol.49Issue(2)：129-132,4.DOI:10.3969/j.issn.0253-9802.2018.02.012
抗苗勒管激素在腹膜型子宫内膜异位症患者卵巢储备功能评估中的价值研究
Study of anti-Müllerian hormone in the assessment of ovarian reserve in patients with peritoneal endometriosis
摘要
Abstract
Objective To investigate whether the serum level of anti-Müllerian hormone (AMH) was affected by the AMH level in the intraperitoneal fluid in patients diagnosed with endometriosis (EMS) without ovarian endometriosis cyst,and analyze the value of AMH in the evaluation of ovarian reserve in patients with peritoneal EMS.Methods Eighteen patients who were diagnosed with simple peritoneal EMS by laparoscope were assigned into group A,and 12 hysteromyoma patients undergoing laparoscopic resection and without history of adverse pregnancy were allocated into group B.The AMH levels of the intraperitoneal fluid and serumwere quantitatively measured by ELISA before and at 1,3 and 6 months after surgery in all patients.The changes in the serum and intraperitoneal fluid levels of AMH at each time point in group A were analyzed.The intraperitoneal fluid and serum levels of AMH were statistically compared between two groups.Results In group A,the AMH levels in the intraperitoneal fluid were significantly higher compared with those in the serum samples at all time points (all P ＜ 0.05).The serum level of AMH at postoperative 1 month was considerably lower than preoperative level,which tended to gradually elevate,whereas it did not restore to preoperative level at postoperative 3 months.The serum level of AMH at postoperative 6 months was still relatively low (all P ＜ 0.008).The AMH level in the intraperitoneal fluid was significantly down-regulated at postoperative 1 month (P ＜ 0.008),and no statistical significance was noted between postoperative 3 and 6 months (both P ＞ 0.008).In group A,the serum levels of AMH at postoperative 1,3 and 6 months were significantly lower than those in group B (all P ＞ 0.05),whereas the AMH levels in the intraperitoneal fluid were dramatically higher compared with those in group B (all P ＜ 0.05).Conclusions No mutual effect is observed between the AMH levels in the intraperitoneal fluid and serum samples of peritoneal EMS patients.Serum AMH level is a sensitive and reliable parameter to evaluate the ovarian reserve of patients with peritoneal EMS.关键词
抗苗勒管激素/腹膜型子宫内膜异位症/卵巢储备功能Key words
Anti-Müllerian hormone/Peritoneal endometriosis/Ovarian reserve引用本文复制引用
李再仪,游泽山,罗宋,程卉..抗苗勒管激素在腹膜型子宫内膜异位症患者卵巢储备功能评估中的价值研究[J].新医学,2018,49(2):129-132,4.基金项目
佛山市科技计划基金(2015AB001165) （2015AB001165）
