新医学2018，Vol.49Issue(3)：186-189,4.DOI:10.3969/j.issn.0253-9802.2018.03.010
依折麦布联合瑞舒伐他汀对STEMI患者发生心血管不良事件的影响
Effect of ezetimibe combined with rosuvastatin on the incidence of adverse cadiovascular events in STEMI patients
摘要
Abstract
Objective To evaluate whether ezetimibe combined with rosuvastatin intensive lipid-lowering therapy can decrease the incidence of adverse cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).Methods A total of 128 STEMI patients were divided into the experimental (ezetimibe combined with rosuvastatin,n =78) and control groups (rosuvastatin,n =50).Patients in both groups were administered with rosuvastatin at a dose of 20 mg.One week later,ezetimibe was given at a dose of l0 mg once daily,supplemented with rosuvastatin at a dose of 10 mg once every night in the experimental group.In the control group,rosuvastatin at a dose of l0 mg was administered once each night.All patients received dual antiplatelet therapy of aspirin plus ticagrelor,metoprolol and perindopril.All patients were followed up for 1 year.Cadiovascular death and myocardial infarction were considered as the endpoint events.The clinical efficacy of lipid lowering was statistically compared between two groups.The frequency of outpatient due to unstable angina was recorded.Results After 1-year treatment,the levels of low-density lipoprotein-cholesterol (LDL-C) and total cholesterol in the experimental group were significantly lower compared with those in the control group (both P ＜ 0.05).In the experimental group,one patient was lost to follow-up due to death.In the experimental group,the frequency of outpatient due to unstable angina was significantly less than that in the control group (P ＜ 0.05).In both groups,no patient terminated the medication therapy due to liver function damage and alternative adverse reactions.Conclusion Ezetimibe combined with rosuvastatin intensive lipid-lowering therapy can decrease the onset and frequency of unstable angina in patients with acute STEMI.关键词
依折麦布/瑞舒伐他汀/急性心肌梗死Key words
Ezetimibe/Rosuvastatin/Acute myocardial infarction引用本文复制引用
张焕基,陈怡锡,吴智文,伍贵富..依折麦布联合瑞舒伐他汀对STEMI患者发生心血管不良事件的影响[J].新医学,2018,49(3):186-189,4.基金项目
福田区科研资助项目(FTWS20160016) （FTWS20160016）
